A computer-regulated bioreactor that uses positive air pressure to deform tissue samples or 3-D cell cultures in vitro, simulating biological compression conditions (see Fig. 1 below).|
- Uses positive pressure to compress samples between a piston and stationary platen on the BioPress™ culture plate yielding up to 14 lbs of force.
- Program multiple frequency, amplitude, and wave changes in one regimen with defined, static or cyclic deformation of cells.
- Valving mechanism regulates pressure to provide specified compression regimen.
- Compatible with Windows 7.
Read more about Applying Mechanical Load to Cells in 3D Culture
Figure 1: Schematic of how compression is applied to tissue samples in a BioPress™ well.
Relevant Tech Reports
Compression System Video
Recent Publications with a Flexcell® Compression Product
Spironolactone promotes autophagy via inhibiting PI3K/AKT/mTOR signalling pathway and reduce adhesive capacity damage in podocytes under mechanical stress
Li D, Lu Z, Xu Z, Ji J, Zheng Z, Lin S, Yan T. Biosci Rep 36(4), 2016. pii: e00355. doi: 10.1042/BSR20160086.
Influence of mechanical compression on human periodontal ligament fibroblasts and osteoblasts
Nettelhoff L, Grimm S, Jacobs C, Walter C, Pabst AM, Goldschmitt J, Wehrbein H. Clin Oral Investig 20(3):621-9, 2016. doi: 10.1007/s00784-015-1542-0. Epub 2015 Aug 6.
BM-MSCs and Bio-Oss complexes enhanced new bone formation during maxillary sinus floor augmentation by promoting differentiation of BM-MSCs
Zhou Q, Yu BH, Liu WC, Wang ZL. In Vitro Cell Dev Biol Anim 2016 Jun 1. [Epub ahead of print].
Engineering the periodontal ligament in hyaluronan-gelatin-type I collagen constructs: upregulation of apoptosis and alterations in gene expression by cyclic compressive strain
Saminathan A, Sriram G, Vinoth JK, Cao T, Meikle MC. Tissue Eng Part A 21(3-4):518-29, 2015. doi: 10.1089/ten.TEA.2014.0221.
Hyaluronic acid secretion by synoviocytes alters under cyclic compressive load in contracted collagen gels
Uehara K, Hara M, Matsuo T, Namiki G, Watanabe M, Nomura Y. Cytotechnology 67(1):19-26, 2015. doi: 10.1007/s10616-013-9669-9.
The effect of mechanical stimulation on mineralization in differentiating osteoblasts in collagen-I scaffolds
Damaraju S, Matyas JR, Rancourt DE, Duncan NA. Tissue Eng Part A 20(23-24): 3142-3153, 2014. doi:10.1089/ten.tea.2014.0026
Construction of collagen gel scaffolds for mechanical stress analysis
Hara M, Nakashima M, Fujii T, Uehara K, Yokono C, Hashizume R, Nomura Y. Biosci Biotechnol Biochem 78(3):458-61, 2014. doi: 10.1080/09168451.2014.882749.
Mechanical compression up-regulates MMP9 through SMAD3 but not SMAD2 modulation in hypertrophic scar fibroblasts
Huang D, Liu YP, Huang YJ, Xie YF, Shen KH, Zhang DW, Mou Y. Connect Tissue Res 55(5-6):391-6, 2014. doi: 10.3109/03008207.2014.959118.
Induction of nerve growth factor expression and release by mechanical and inflammatory stimuli in chondrocytes: possible involvement in osteoarthritis pain
Pecchi E, Priam S, Gosset M, Pigenet A, Sudre L, Laiguillon MC, Berenbaum F, Houard X. Arthritis Res Ther 16(1):R16, 2014. doi: 10.1186/ar4443.
Investigating conversion of endplate chondrocytes induced by intermittent cyclic mechanical unconfined compression in three-dimensional cultures
Xu HG, Zhang W, Zheng Q, Yu YF, Deng LF, Wang H, Liu P, Zhang M. European Journal of Histochemistry 58:2415, 2014.
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