UniFlex

UniFlex® Culture Plates
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Flexible-bottomed culture plate that works with the FX-5000™ Tension System to provide uniaxial strain to cells in monolayer culture.
*5% Savings (based on buying 40 plates at the individual price)


Applications of UniFlex® Culture Plates
  • Mechanical Load - use with the FX-5000™ Tension System to research the effects of uniaxial tensile strain on cells in monolayer culture.
  • Softer Substrate - provides a softer substrate for cell growth when compared to standard plastic culture dishes, which better mimics in situ conditions for some cell types like trabecular meshwork cells (see Aga et al. Invest Ophthalmol Vis Sci 55(9):5497-509, 2014).
  • Matrix Coated Surface - culture plate surfaces are coated with various matrix proteins to better simulate in vivo conditions (see Tech Report 106: Matrix Bonded Growth Surfaces. Growing Cells in a More Natural Matrix Environment).
  • Microgrooved Channels - plates have been modified to hold microgrooved channels molded with PDMS. Plates can then be mechanically loaded with the FX-5000™ Tension System, if desired (see Jones et al. J Biomech 38(8):1653-1664, 2005).
Read more about Applying Mechanical Load to Cells in Monolayer Culture

Arctangle

Figure 1: A) Arctangle® loading post. B) UniFlex® well. C) UniFlex® Culture Plate resting atop Arctangle® Loading Station™.

Relevant Tech Reports & Other Information
Recent Publications with a Flexcell® Uniaxial Tension Product

Dynamic mechanical and nanofibrous topological combinatory cues designed for periodontal ligament engineering
Kim JH, Kang MS, Eltohamy M, Kim TH, Kim HW. PLoS One 11(3):e0149967, 2016. doi: 10.1371/journal.pone.0149967.

Effects of mechanical stretch on cell proliferation and matrix formation of mesenchymal stem cell and anterior cruciate ligament fibroblast
Sun L, Qu L, Zhu R, Li H, Xue Y, Liu X, Fan J, Fan H. Stem Cells International 2016(9842075), 10 pages, 2016. doi:10.1155/2016/9842075.

Comparative analysis of mesenchymal stem cell and embryonic tendon progenitor cell response to embryonic tendon biochemical and mechanical factors
Brown JP, Galassi TV, Stoppato M, Schiele NR, Kuo CK. Stem Cell Res Ther 6:89, 2015. doi: 10.1186/s13287-015-0043-z.

Surface modification of uniaxial cyclic strain cell culture platform with temperature-responsive polymer for cell sheet detachment
Lee EL, Bendre HH, Kalmykov A, Wong JY. J Mater Chem B Mater Biol Med 3(40):7899-7902, 2015. Epub 2015 Aug 19.

Competition between cap and basal actin fiber orientation in cells subjected to contact guidance and cyclic strain
Tamiello C, Bouten CV, Baaijens FP. Sci Rep 5:8752, 2015. doi: 10.1038/srep08752.

Mechanical stretch assays in cell culture systems
Tondon A, Haase C, Kaunas R. In: Handbook of Imaging in Biological Mechanics, ed. Neu CP, Genin GM. CRC Press: Boca Raton, 2015.

Embryonic mechanical and soluble cues regulate tendon progenitor cell gene expression as a function of developmental stage and anatomical origin
Brown JP, Finley VG, Kuo CK. J Biomech 47(1):214-22, 2014. doi: 10.1016/j.jbiomech.2013.09.018.

Uniaxial cyclic strain of human adipose-derived mesenchymal stem cells and C2C12 myoblasts in coculture
Dugan JM, Cartmell SH, Gough JE. J Tissue Eng 5:2041731414530138, 2014. doi: 10.1177/2041731414530138.

Multistage adipose-derived stem cell myogenesis: an experimental and modeling study
Huri PY, Wang A, Spector AA, Grayson WL. Cellular and Molecular Bioengineering 7(4):497-509, 2014.

Mechanically loaded myotubes affect osteoclast formation
Juffer P, Jaspers RT, Klein-Nulend J, Bakker AD. Calcif Tissue Int 94(3):319-26, 2014. doi: 10.1007/s00223-013-9813-8.

In vitro study of the impact of mechanical tension on the dermal fibroblast phenotype in the context of skin wound healing
Rolin GL, Binda D, Tissot M, Viennet C, Saas P, Muret P, Humbert P. J Biomech 47(14):3555-61, 2014. doi: 10.1016/j.jbiomech.2014.07.015.

Angiogenic microenvironment augments impaired endothelial responses under diabetic conditions
Sheikh AQ, Kuesel C, Taghian T, Hurley JR, Huang W, Wang Y, Hinton RB, Narmoneva DA. Am J Physiol Cell Physiol 306(8):C768-78, 2014. doi: 10.1152/ajpcell.00201.2013.

Primary cilia disassembly down-regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes
Thompson CL, Chapple JP, Knight MM. Osteoarthritis Cartilage 22(3):490-8, 2014. doi: 10.1016/j.joca.2013.12.016.


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