Endothelial Cells

CARDIOVASCULAR ENDOTHELIAL CELLS

Ali MH, Pearlstein DP, Mathieu CE, Schumacker PT. Mitochondrial requirement for endothelial responses to cyclic strain: implications for mechanotransduction. Am J Physiol Lung Cell Mol Physiol 287(3):L486-L496, 2004.

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Altalhi W, Sun X, Sivak JM, Husain M, Nunes SS. Diabetes impairs arterio-venous specification in engineered vascular tissues in a perivascular cell recruitment-dependent manner. Biomaterials 119:23-32, 2017.

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Awolesi MA, Sessa WC, Sumpio BE. Cyclic strain upregulates nitric oxide synthase in cultured bovine aortic endothelial cells. J Clin Invest 96(3):1449-1454, 1995.

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Azuma N, Duzgun SA, Ikeda M, Kito H, Akasaka N, Sasajima T, Sumpio BE. Endothelial cell response to different mechanical forces. J Vasc Surg 32(4):789-794, 2000.

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Baker PN, Stranko CP, Davidge ST, Davies PS, Roberts JM. Mechanical stress eliminates the effects of plasma from patients with preeclampsia on endothelial cells. Am J Obstet Gynecol 174(2):730-6, 1996.

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Brophy CM, Mills I, Rosales O, Isales C, Sumpio BE. Phospholipase C: a putative mechanotransducer for endothelial cell response to acute hemodynamic changes. Biochem Biophys Res Commun 190(2):576-581, 1993.

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Cevallos M, Riha GM, Wang X, Yang H, Yan S, Li M, Chai H, Yao Q, Chen C. Cyclic strain induces expression of specific smooth muscle cell markers in human endothelial cells. Differentiation 74(9-10):552-561, 2006.

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Chang H, Wang BW, Kuan P, Shyu KG. Cyclical mechanical stretch enhances angiopoietin-2 and Tie2 receptor expression in cultured human umbilical vein endothelial cells. Clin Sci (Lond) 104(4):421-428, 2003.

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Cheng JJ, Chao YJ, Wang DL. Cyclic strain activates redox-sensitive proline-rich tyrosine kinase 2 (PYK2) in endothelial cells. J Biol Chem 277(50):48152-48157, 2002.

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Cheng JJ, Wung BS, Chao YJ, Wang DL. Cyclic strain enhances adhesion of monocytes to endothelial cells by increasing intercellular adhesion molecule-1 expression. Hypertension 28(3):386-391, 1996.

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Cheng JJ, Wung BS, Chao YJ, Wang DL. Cyclic strain-induced reactive oxygen species involved in ICAM-1 gene induction in endothelial cells. Hypertension 31(1):125-30, 1998.

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Cheng JJ, Wung BS, Chao YJ, Wang DL. Sequential activation of protein kinase C (PKC)-alpha and PKC-epsilon contributes to sustained Raf/ERK1/2 activation in endothelial cells under mechanical strain. J Biol Chem 276(33):31368-31375, 2001.

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Coen P, Cummins P, Birney Y, Devery R, Cahill P. Modulation of nitric oxide and 6-keto-prostaglandin F(1alpha) production in bovine aortic endothelial cells by conjugated linoleic acid. Endothelium 11(3-4):211-20, 2004.

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Cohen CR, Mills I, Du W, Kamal K, Sumpio BE. Activation of the adenylyl cyclase/cyclic AMP/protein kinase A pathway in endothelial cells exposed to cyclic strain. Exp Cell Res 231(1):184-189, 1997.

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Cummins PM, Cotter EJ, Cahill PA. Hemodynamic regulation of metallopeptidases within the vasculature. Protein Pept Lett 11(5):433-442, 2004.

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Cummins PM, von Offenberg Sweeney N, Killeen MT, Birney YA, Redmond EM, Cahill PA. Cyclic strain-mediated matrix metalloproteinase regulation within the vascular endothelium: a force to be reckoned with. Am J Physiol Heart Circ Physiol 292:H28–H42, 2007.

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Dekker RJ, van Thienen JV, Rohlena J, de Jager SC, Elderkamp YW, Seppen J, de Vries CJ, Biessen EA, van Berkel TJ, Pannekoek H, Horrevoets AJ. Endothelial KLF2 links local arterial shear stress levels to the expression of vascular tone-regulating genes. Am J Pathol 167(2):609-618, 2005.

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Dong R, Zhang K, Wang YL, Zhang F, Cao J, Zheng JB, Zhang HJ. MiR-551b-5p contributes to pathogenesis of vein graft failure via upregulating early growth response-1 expression. Chin Med J (Engl) 130(13):1578-1585, 2017.

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Du W, Mills I, Sumpio BE. Cyclic strain causes heterogeneous induction of transcription factors, AP-1, CRE binding protein and NF-B, in endothelial cells: species and vascular bed diversity. Journal of Biomechanics 28(12):1485-149, 1995.

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Evans L, Frenkel L, Brophy CM, Rosales O, Sudhaker CB, Li G, Du W, Sumpio BE. Activation of diacylglycerol in cultured endothelial cells exposed to cyclic strain. Am J Physiol 272(2 Pt 1):C650-C656, 1997.

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Fisslthaler B, Boengler K, Fleming I, Schaper W, Busse R, Deindl E. Identification of a cis-element regulating transcriptional activity in response to fluid shear stress in bovine aortic endothelial cells. Endothelium 10(4-5):267-75, 2003.

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Fisslthaler B, Popp R, Michaelis UR, Kiss L, Fleming I, Busse R. Cyclic stretch enhances the expression and activity of coronary endothelium-derived hyperpolarizing factor synthase. Hypertension 38(6):1427-1432, 2001.

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Freese C, Anspach L, Deller RC, Richards SJ, Gibson MI, Kirkpatrick CJ, Unger RE. Gold nanoparticle interactions with endothelial cells cultured under physiological conditions. Biomater Sci 5(4):707-717, 2017.

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Fujioka K, Azuma N, Kito H, Gahtan V, Esato K, Sumpio BE. Role of caveolin in hemodynamic force-mediated endothelial changes. J Surg Res 92(1):7-10, 2000.

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Gawlak G, Tian Y, O'Donnell JJ 3rd, Tian X, Birukova AA, Birukov KG. Paxillin mediates stretch-induced Rho signaling and endothelial permeability via assembly of paxillin-p42/44MAPK-GEF-H1 complex. FASEB J 28(7):3249-60, 2014.

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Ghosh K, Thodeti CK, Dudley AC, Mammoto A, Klagsbrun M, Ingber DE. Tumor-derived endothelial cells exhibit aberrant Rho-mediated mechanosensing and abnormal angiogenesis in vitro. Proc Natl Acad Sci U S A 105(32):11305-11310, 2008.

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Goettsch C, Goettsch W, Arsov A, Hofbauer LC, Bornstein SR, Morawietz H. Long-term cyclic strain downregulates endothelial Nox4. Antioxid Redox Signal 11(10):2385-2397, 2009.

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Grigoryev DN, Ma SF, Irizarry RA, Ye SQ, Quackenbush J, Garcia JG. Orthologous gene-expression profiling in multi-species models: search for candidate genes. Genome Biol 5(5):R34, 2004.

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Haga M, Chen A, Gortler D, Dardik A, Sumpio BE. Shear stress and cyclic strain may suppress apoptosis in endothelial cells by different pathways. Endothelium 10(3):149-57, 2003.

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Hishikawa K, Luscher TF. Pulsatile stretch stimulates superoxide production in human aortic endothelial cells. Circulation 96(10):3610-3616, 1997.

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Hoshino Y, Nishimura K, Sumpio BE. Phosphatase PTEN is inactivated in bovine aortic endothelial cells exposed to cyclic strain. J Cell Biochem 100(2):515-526, 2007.

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Howard AB, Alexander RW, Nerem RM, Griendling KK, Taylor WR. Cyclic strain induces an oxidative stress in endothelial cells. Am J Physiol Cell Physiol 272(2):C421-C427, 1997.

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Hu J, Liu Y. Cyclic strain enhances cellular uptake of nanoparticles. Journal of Nanomaterials 2015:953584, 2015.

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Iba T, Mills I, Sumpio BE. Intracellular cyclic AMP levels in endothelial cells subjected to cyclic strain in vitro. J Surg Res 52(6):625-630, 1992.

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Iba T, Shin T, Sonoda T, Rosales O, Sumpio BE. Stimulation of endothelial secretion of tissue-type plasminogen activator by repetitive stretch. J Surg Res 50(5):457-460, 1991.

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Iba T, Sumpio BE. Morphological response of human endothelial cells subjected to cyclic strain in vitro. Microvasc Res 42(3):245-254, 1991.

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Ikeda M, Kito H, Sumpio BE. Phosphatidylinositol-3 kinase dependent MAP kinase activation via p21ras in endothelial cells exposed to cyclic strain. Biochem Biophys Res Commun 257(3):668-671, 1999.

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Ikeda M, Takei T, Mills I, Kito H, Sumpio BE. Extracellular signal-regulated kinases 1 and 2 activation in endothelial cells exposed to cyclic strain. Am J Physiol Heart Circ Physiol 276:H614-H622, 1999.

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Ikeda M, Takei T, Mills I, Sumpio BE. Calcium-independent activation of extracellular signal-regulated kinases 1 and 2 by cyclic strain. Biochem Biophys Res Commun 247(2):462-465, 1998.

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Jiang J, Qi YX, Zhang P, Gu WT, Yan ZQ, Shen BR, Yao QP, Kong H, Chien S, Jiang ZL. Involvement of Rab28 in NF-B nuclear transport in endothelial cells. PLoS One 8(2):e56076, 2013.

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Jiang Y, Wang Y, Tang G. Cyclic tensile strain promotes the osteogenic differentiation of a bone marrow stromal cell and vascular endothelial cell co-culture system. Arch Biochem Biophys 607:37-43, 2016.

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Juan SH, Chen JJ, Chen CH, Lin H, Cheng CF, Liu JC, Hsieh MH, Chen YL, Chao HH, Chen TH, Chan P, Cheng TH. 17-estradiol inhibits cyclic strain-induced endothelin-1 gene expression within vascular endothelial cells. Am J Physiol Heart Circ Physiol 287(3):H1254-H1261, 2004.

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Kim JI, Cordova AC, Hirayama Y, Madri JA, Sumpio BE. Differential effects of shear stress and cyclic strain on Sp1 phosphorylation by protein kinase C  modulates membrane type 1-matrix metalloproteinase in endothelial cells. Endothelium 15(1):33-42, 2008.

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Kito H, Yokoyama C, Inoue H, Tanabe T, Nakajima N, Sumpio BE. Cyclooxygenase expression in bovine aortic endothelial cells exposed to cyclic strain. Endothelium 6(2):107-112, 1998.

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Kobayashi K, Tanaka M, Nebuya S, Kokubo K, Fukuoka Y, Harada Y, Kobayashi H, Noshiro M, Inaoka H. Temporal change in IL-6 mRNA and protein expression produced by cyclic stretching of human pulmonary artery endothelial cells. Int J Mol Med 30(3):509-13, 2012.

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Korff T, Aufgebauer K, Hecker M. Cyclic stretch controls the expression of CD40 in endothelial cells by changing their transforming growth factor-1 response. Circulation 116(20):2288-2297, 2007.

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Korff T, Ernst E, Nobiling R, Feldner A, Reiss Y, Plate KH, Fiedler U, Augustin HG, Hecker M. Angiopoietin-1 mediates inhibition of hypertension-induced release of angiopoietin-2 from endothelial cells. Cardiovasc Res 94(3):510-8, 2012.

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Kou B, Zhang J, Singer DR. Effects of cyclic strain on endothelial cell apoptosis and tubulogenesis are dependent on ROS production via NAD(P)H subunit p22phox. Microvasc Res 77(2):125-133, 2009.

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Kuk H, Arnold C, Meyer R, Hecker M, Korff T. Magnolol inhibits venous remodeling in mice. Sci Rep 7(1):17820, 2017. doi: 10.1038/s41598-017-17910-0.

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Lauth M, Cattaruzza M, Hecker M. ACE inhibitor and AT1 antagonist blockade of deformation-induced gene expression in the rabbit jugular vein through B2 receptor activation. Arterioscler Thromb Vasc Biol 21(1):61-6, 2001.

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Lauth M, Wagner AH, Cattaruzza M, Orzechowski HD, Paul M, Hecker M. Transcriptional control of deformation-induced preproendothelin-1 gene expression in endothelial cells. J Mol Med 78(8):441-450, 2000.

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Lee T, Kim SJ, Sumpio BE. Role of PP2A in the regulation of p38 MAPK activation in bovine aortic endothelial cells exposed to cyclic strain. J Cell Physiol 194(3):349-355, 2003.

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Li W, Sumpio BE. Strain-induced vascular endothelial cell proliferation requires PI3K-dependent mTOR-4E-BP1 signal pathway. Am J Physiol Heart Circ Physiol 288(4):H1591-1597, 2005.

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Loperena R, Chen W, Kirabo A, Harrison DG. Hypertensive mechanical stretch: A model for monocyte-derived dendritic cell differentiation [abstract]. The FASEB Journal 30(1):723.4, 2016.

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Mai J, Hu Q, Xie Y, Su S, Qiu Q, Yuan W, Yang Y, Song E, Chen Y, Wang J. Dyssynchronous pacing triggers endothelial-mesenchymal transition through heterogeneity of mechanical stretch in a canine model. Circ J 79(1):201-9, 2015.

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Martin FA, McLoughlin A, Rochfort KD, Davenport C, Murphy RP, Cummins PM. Regulation of thrombomodulin expression and release in human aortic endothelial cells by cyclic strain. PLoS One 9(9):e108254, 2014.

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Mascarenhas JB, Tchourbanov AY, Fan H, Danilov SM, Wang T, Garcia JG. Mechanical stress and single nucleotide variants regulate alternative splicing of the MYLK gene. Am J Respir Cell Mol Biol 56(1):29-37, 2017. doi: 10.1165/rcmb.2016-0053OC.

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McIntosh CT, Warnock JN. Side-specific characterization of aortic valve endothelial cell adhesion molecules under cyclic strain. The Journal of Heart Valve Disease 22:631-639, 2013.

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Metzler SA, Pregonero CA, Butcher JT, Burgess SC, Warnock JN. Cyclic strain regulates pro-inflammatory protein expression in porcine aortic valve endothelial cells. J Heart Valve Dis 17(5):571-577, 2008.

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Moldobaeva A, Jenkins J, Wagner E. Effects of distension on airway inflammation and venular P-selectin expression. Am J Physiol Lung Cell Mol Physiol 295(5):L941-L948, 2008.

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Morrow D, Cullen JP, Cahill PA, Redmond EM. Cyclic strain regulates the Notch/CBF-1 signaling pathway in endothelial cells: role in angiogenic activity. Arterioscler Thromb Vasc Biol 27:1289-1296, 2007.

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Murata K, Mills I, Sumpio BE. Protein phosphatase 2A in stretch-induced endothelial cell proliferation. J Cell Biochem 63(3):311-319, 1996.

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Neto F, Klaus-Bergmann A, Ong YT, Alt S, Vion AC, Szymborska A, Carvalho JR, Hollfinger I, Bartels-Klein E, Franco CA, Potente M, Gerhardt H. YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development. Elife 2018 Feb 5;7. pii: e31037. doi: 10.7554/eLife.31037. [Epub ahead of print]

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Nishimura K, Li W, Hoshino Y, Kadohama T, Asada H, Ohgi S, Sumpio BE. Role of AKT in cyclic strain-induced endothelial cell proliferation and survival. Am J Physiol Cell Physiol 290(3):C812-C821, 2006.

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Okada M, Matsumori A, Ono K, Furukawa Y, Shioi T, Iwasaki A, Matsushima K, Sasayama S. Cyclic stretch upregulates production of interleukin-8 and monocyte chemotactic and activating factor/monocyte chemoattractant protein-1 in human endothelial cells. Arterioscler Thromb Vasc Biol 18(6):894-901, 1998.

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Pikkarainen S, Tokola H, Kerkela R, Ilves M, Makinen M, Orzechowski HD, Paul M, Vuolteenaho O, Ruskoaho H. Inverse regulation of preproendothelin-1 and endothelin-converting enzyme-1beta genes in cardiac cells by mechanical load. Am J Physiol Regul Integr Comp Physiol 290(6):R1639-R1645, 2006.

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Rakugi H, Yu H, Kamitani A, Nakamura Y, Ohishi M, Kamide K, Nakata Y, Takami S, Higaki J, Ogihara T. Links between hypertension and myocardial infarction. American Heart Journal 132(1 Pt 2 Su):213-221, 1996.

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Regnault V, Perret-Guillaume C, Kearney-Schwartz A, Max JP, Labat C, Louis H, Wahl D, Pannier B, Lecompte T, Weryha G, Challande P, Safar ME, Benetos A, Lacolley P. Tissue factor pathway inhibitor: a new link among arterial stiffness, pulse pressure, and coagulation in postmenopausal women. Arterioscler Thromb Vasc Biol 31(5):1226-1232, 2011.

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Rosales OR, Isales CM, Barrett PQ, Brophy C, Sumpio BE. Exposure of endothelial cells to cyclic strain induces elevations of cytosolic Ca2+ concentration through mobilization of intracellular and extracellular pools. Biochem J 326(Pt 2):385-92, 1997.

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Rosales OR, Sumpio BE. Changes in cyclic strain increase inositol trisphosphate and diacylglycerol in endothelial cells. Am J Physiol Cell Physiol 262(4):C956-C962, 1992.

Abstract Aricle

Schneider SW, Yano Y, Sumpio BE, Jena BP, Geibel JP, Gekle M, Oberleithner H. Rapid aldosterone-induced cell volume increase of endothelial cells measured by the atomic force microscope. Cell Biol Int 21(11):759-768, 1997.

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Segurola RJ Jr, Oluwole B, Mills I, Yokoyama C, Tanabe T, Kito H, Nakajima N, Sumpio BE. Cyclic strain is a weak inducer of prostacyclin synthase expression in bovine aortic endothelial cells. J Surg Res 69(1):135-138, 1997.

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Sheikh AQ, Kuesel C, Taghian T, Hurley JR, Huang W, Wang Y, Hinton RB, Narmoneva DA. Angiogenic microenvironment augments impaired endothelial responses under diabetic conditions. Am J Physiol Cell Physiol 306(8):C768-78, 2014.

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Steadman E, Meza D, Rubenstein DA, Yin W. Endothelial cell mechanical responses are dependent on both fluid shear stress and tensile strain. The FASEB Journal 31(1 Supplement), 689-16, 2017.

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Sumpio BE, Banes AJ, Buckley M, Johnson G Jr. Alterations in aortic endothelial cell morphology and cytoskeletal protein synthesis during cyclic tensional deformation. J Vasc Surg 7(1):130-138, 1988.

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Sumpio BE, Banes AJ, Levin LG, Johnson G Jr. Mechanical stress stimulates aortic endothelial cells to proliferate. J Vasc Surg 6(3):252-256, 1987.

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Sumpio BE, Banes AJ, Link GW, Iba T. Modulation of endothelial cell phenotype by cyclic stretch: inhibition of collagen production. J Surg Res 48(5):415-420, 1990.

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Sumpio BE, Banes AJ. Prostacyclin synthetic activity in cultured aortic endothelial cells undergoing cyclic mechanical deformation. Surgery 104(2):383-389, 1988.

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Sumpio BE, Chang R, Xu WJ, Wang XJ, Du W. Regulation of tPA in endothelial cells exposed to cyclic strain: role of CRE, AP-2, and SSRE binding sites. Am J Physiol Cell Physiol 273:C1441-C1448, 1997.

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Sumpio BE, Du W, Galagher G, Wang X, Khachigian LM, Collins T, Gimbrone MA Jr, Resnick N. Regulation of PDGF-B in endothelial cells exposed to cyclic strain. Arterioscler Thromb Vasc Biol 18(3):349-355, 1998.

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Sun X, Elangovan VR, Mapes B, Camp SM, Sammani S, Saadat L, Ceco E, Ma SF, Flores C, MacDougall MS, Quijada H, Liu B, Kempf CL, Wang T, Chiang ET, Garcia JG. The NAMPT promoter is regulated by mechanical stress, signal transducer and activator of transcription 5, and acute respiratory distress syndrome-associated genetic variants. Am J Respir Cell Mol Biol 51(5):660-7, 2014.

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Thodeti CK, Matthews B, Ravi A, Mammoto A, Ghosh K, Bracha AL, Ingber DE. TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling. Circ Res 104(9):1123-1130, 2009.

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Tomanek RJ, Zheng W. Role of growth factors in coronary morphogenesis. Tex Heart Inst J 29(4):250-254, 2002.

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Ulfhammer E, Ridderstrale W, Andersson M, Karlsson L, Hrafnkelsdottir T, Jern S. Prolonged cyclic strain impairs the fibrinolytic system in cultured vascular endothelial cells. J Hypertens 23(8):1551-1557, 2005.

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Upchurch GR Jr, Loscalzo J, Banes AJ. Changes in the amplitude of cyclic load biphasically modulate endothelial cell DNA synthesis and division. Vasc Med 2(1):19-24, 1997.

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van Wamel AJ, Ruwhof C, van der Valk-Kokshoom LE, Schrier PI, van der Laarse A. The role of angiotensin II, endothelin-1 and transforming growth factor-beta as autocrine/paracrine mediators of stretch-induced cardiomyocyte hypertrophy. Mol Cell Biochem 218(1-2):113-124, 2001.

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van Wamel AJ, Ruwhof C, van der Valk-Kokshoorn LJ, Schrier PI, van der Laarse A. Stretch-induced paracrine hypertrophic stimuli increase TGF-beta1 expression in cardiomyocytes. Mol Cell Biochem 236(1-2):147-153, 2002.

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Vion AC, Birukova AA, Boulanger CM, Birukov KG. Mechanical forces stimulate endothelial microparticle generation via caspase-dependent apoptosis-independent mechanism. Pulm Circ 3(1):95-9, 2013.

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Vollmer T, Hinse D, Kleesiek K, Dreier J. Interactions between endocarditis-derived Streptococcus gallolyticus subsp. Gallolyticus isolates and human endothelial cells. BMC Microbiology 10:78, 2010.

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von Offenberg Sweeney N, Cummins PM, Birney YA, Cullen JP, Redmond EM, Cahill PA. Cyclic strain-mediated regulation of endothelial matrix metalloproteinase-2 expression and activity. Cardiovascular Research 63(4):625-634, 2004.

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von Offenberg Sweeney N, Cummins PM, Birney YA, Redmond EM, Cahill PA. Cyclic strain-induced endothelial MMP-2: role in vascular smooth muscle cell migration. Biochemical and Biophysical Research Communications 320:325–333, 2004.

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von Offenberg Sweeney, Cummins PM, Cotter EJ, Fitzpatrick PA, Birney YA, Redmond EM, Cahill PA. Cyclic strain-mediated regulation of vascular endothelial cell migration and tube formation. Biochemical and Biophysical Research Communications 329:573–582, 2005.

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Wang C, Jiao C, Hanlon HD, Zheng W, Tomanek RJ, Schatteman GC. Mechanical, cellular, and molecular factors interact to modulate circulating endothelial cell progenitors. Am J Physiol Heart Circ Physiol 286(5):H1985-H1993, 2004.

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Wang DL, Wung BS, Peng YC, Wang JJ. Mechanical strain increases endothelin-1 gene expression via protein kinase C pathway in human endothelial cells. J Cell Physiol 163(2):400-406, 1995.

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Wang DL, Wung BS, Shyy YJ, Lin CF, Chao YJ, Usami S, Chien S. Mechanical strain induces monocyte chemotactic protein-1 gene expression in endothelial cells. Effects of mechanical strain on monocyte adhesion to endothelial cells. Circ Res 77(2):294-302, 1995.

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Wang L, Bao H, Wang KX, Zhang P, Yao QP, Chen XH, Huang K, Qi YX, Jiang ZL. Secreted miR-27a induced by cyclic stretch modulates the proliferation of endothelial cells in hypertension via GRK6. Sci Rep 7:41058, 2017.

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Widmann MD, Letsou GV, Phan S, Baldwin JC, Sumpio BE. Isolation and characterization of rabbit cardiac endothelial cells: response to cyclic strain and growth factors in vitro. Journal of Surgical Research 53(4):331-334, 1992.

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Wilson CJ, Kasper G, Schütz MA, Duda GN. Cyclic strain disrupts endothelial network formation on Matrigel. Microvasc Res 78(3):358-63, 2009.

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Woodell JE, LaBerge M, Langan EM 3rd, Hilderman RH. In vitro strain-induced endothelial cell dysfunction determined by DNA synthesis. Proc Inst Mech Eng [H] 217(1):13-20, 2003.

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Woodell JE, LaBerge M, Langan EM 3rd, Hilderman RH. P1,P4-diadenosine 5'-tetraphosphate induced DNA synthesis in mechanically injured cultured endothelial cells. Proc Inst Mech Eng [H] 217(1):21-26, 2003.

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Wung BS, Cheng JJ, Chao YJ, Hsieh HJ, Wang DL. Modulation of Ras/Raf/extracellular signal-regulated kinase pathway by reactive oxygen species is involved in cyclic strain-induced early growth response-1 gene expression in endothelial cells. Circ Res 84(7):804-812, 1999.

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Wung BS, Cheng JJ, Chao YJ, Lin J, Shyy YJ, Wang DL. Cyclical strain increases monocyte chemotactic protein-1 secretion in human endothelial cells. Am J Physiol Heart Circ Physiol 270(4):H1462-H1468, 1996.

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Wung BS, Cheng JJ, Hsieh HJ, Shyy YJ, Wang DL. Cyclic strain-induced monocyte chemotactic protein-1 gene expression in endothelial cells involves reactive oxygen species activation of activator protein 1. Circ Res 81(1):1-7, 1997.

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Wung BS, Cheng JJ, Shyue SK, Wang DL. NO modulates monocyte chemotactic protein-1 expression in endothelial cells under cyclic strain. Arterioscler Thromb Vasc Biol 21(12):1941-1947, 2001.

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Yamaguchi S, Yamaguchi M, Yatsuyanagi E, Yun SS, Nakajima N, Madri JA, Sumpio BE. Cyclic strain stimulates early growth response gene product 1-mediated expression of membrane type 1 matrix metalloproteinase in endothelium. Lab Invest 82(7):949-956, 2002.

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Yano Y, Geibel J, Sumpio BE. Cyclic strain induces reorganization of integrin alpha5 beta1 and alpha2 beta1 in human umbilical vein endothelial cells. J Cell Biochem 64(3):505-513, 1997.

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Yano Y, Geibel J, Sumpio BE. Tyrosine phosphorylation of pp125FAK and paxillin in aortic endothelial cells induced by mechanical strain. Am J Physiol Cell Physiol 271:C635-C649, 1996.

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Yano Y, Saito Y, Narumiya S, Sumpio BE. Involvement of rho p21 in cyclic strain-induced tyrosine phosphorylation of focal adhesion kinase (pp125FAK), morphological changes and migration of endothelial cells. Biochem Biophys Res Commun 224(2):508-515, 1996.

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Zheng W, Christensen LP, Tomanek RJ. Stretch induces upregulation of key tyrosine kinase receptors in microvascular endothelial cells. Am J Physiol Heart Circ Physiol 287(6):H2739-H2745, 2004.

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Zheng W, Seftor EA, Meininger CJ, Hendrix MJ, Tomanek RJ. Mechanisms of coronary angiogenesis in response to stretch: role of VEGF and TGF-. Am J Physiol Heart Circ Physiol 280(2):H909-H917, 2001.

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Zheng W, Christensen LP, Tomanek RJ. Differential effects of cyclic and static stretch on coronary microvascular endothelial cell receptors and vasculogenic/angiogenic responses. Am J Physiol Heart Circ Physiol 295:H794–H800, 2008.

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PULMONARY ENDOTHELIAL CELLS

Abdulnour RE, Peng X, Finigan JH, Han EJ, Hasan EJ, Birukov KG, Reddy SP, Watkins JE 3rd, Kayyali US, Garcia JG, Tuder RM, Hassoun PM. Mechanical stress activates xanthine oxidoreductase through MAP kinase-dependent pathways. Am J Physiol Lung Cell Mol Physiol 291(3):L345-L353, 2006.

Abstract Article

Adyshev DM, Elangovan VR, Moldobaeva N, Mapes B, Sun X, Garcia JG. Mechanical stress induces pre-B-cell colony-enhancing factor/NAMPT expression via epigenetic regulation by miR-374a and miR-568 in human lung endothelium. Am J Respir Cell Mol Biol 50(2):409-18, 2014.

Abstract Article

Ali MH, Mungai PT, Schumacker PT. Stretch-induced phosphorylation of focal adhesion kinase in endothelial cells: role of mitochondrial oxidants. Am J Physiol Lung Cell Mol Physiol 291(1):L38-L45, 2006.

Abstract Article

Birukov KG, Jacobson JR, Flores AA, Ye SQ, Birukova AA, Verin AD, Garcia JG. Magnitude-dependent regulation of pulmonary endothelial cell barrier function by cyclic stretch. Am J Physiol Lung Cell Mol Physiol 285(4):L785-L797, 2003.

Abstract Article

Birukova AA, Chatchavalvanich S, Rios A, Kawkitinarong K, Garcia JG, Birukov KG. Differential regulation of pulmonary endothelial monolayer integrity by varying degrees of cyclic stretch. Am J Pathol 168(5):1749-1761, 2006.

Abstract Article

Birukova AA, Fu P, Xing J, Cokic I, Birukov KG. Lung endothelial barrier protection by iloprost in the 2-hit models of ventilator-induced lung injury (VILI) involves inhibition of Rho signaling. Transl Res 155(1):44-54, 2010.

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Birukova AA, Fu P, Xing J, Yakubov B, Cokic I, Birukov KG. Mechanotransduction by GEF-H1 as a novel mechanism of ventilator-induced vascular endothelial permeability. Am J Physiol Lung Cell Mol Physiol 298(6):L837-848, 2010.

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Birukova AA, Moldobaeva N, Xing J, Birukov KG. Magnitude-dependent effects of cyclic stretch on HGF- and VEGF-induced pulmonary endothelial remodeling and barrier regulation. Am J Physiol Lung Cell Mol Physiol 295(4):L612-L623, 2008.

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Birukova AA, Rios A, Birukov KG. Long-term cyclic stretch controls pulmonary endothelial permeability at translational and post-translational levels. Exp Cell Res 314(19):3466-3477, 2008.

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Birukova AA, Tian Y, Meliton A, Leff A, Wu T, Birukov KG. Stimulation of Rho signaling by pathologic mechanical stretch is a "second hit" to Rho-independent lung injury induced by IL-6. Am J Physiol Lung Cell Mol Physiol 302(9):L965-75, 2012.

Abstract Article

Chen W, Epshtein Y, Ni X, Dull RO, Cress AE, Garcia JG, Jacobson JR. Role of integrin β4 in lung endothelial cell inflammatory responses to mechanical stress. Sci Rep 5:16529, 2015.

Abstract Article

Dong WW, Liu YJ, Lv Z, Mao YF, Wang YW, Zhu XY, Jiang L. Lung endothelial barrier protection by resveratrol involves inhibition of HMGB1 release and HMGB1-induced mitochondrial oxidative damage via an Nrf2-dependent mechanism. Free Radic Biol Med 88(Pt B):404-16, 2015.

Abstract Article

Dubrovskyi O, Birukova AA, Birukov KG. Measurement of local permeability at subcellular level in cell models of agonist- and ventilator-induced lung injury. Lab Invest 93(2):254-63, 2013.

Abstract Article

Elangovan VR, Camp SM, Kelly GT, Desai AA, Adyshev D, Sun X, Black SM, Wang T, Garcia JG. Endotoxin- and mechanical stress–induced epigenetic changes in the regulation of the nicotinamide phosphoribosyltransferase promoter. Pulmonary Circulation 6(4):539-544, 2016.

Abstract Article

Haseneen NA, Vaday GG, Zucker S, Foda HD. Mechanical stretch induces MMP-2 release and activation in lung endothelium: role of EMMPRIN. Am J Physiol Lung Cell Mol Physiol 284(3):L541-L547, 2003.

Abstract Article

Gawlak G, Tian Y, O'Donnell JJ 3rd, Tian X, Birukova AA, Birukov KG. Paxillin mediates stretch-induced Rho signaling and endothelial permeability via assembly of paxillin-p42/44MAPK-GEF-H1 complex. FASEB J 28(7):3249-60, 2014.

Abstract Article

Grigoryev DN, Ma SF, Irizarry RA, Ye SQ, Quackenbush J, Garcia JG. Orthologous gene-expression profiling in multi-species models: search for candidate genes. Genome Biol 5(5):R34, 2004.

Abstract Article

Kobayashi K, Tanaka M, Nebuya S, Kokubo K, Fukuoka Y, Harada Y, Kobayashi H, Noshiro M, Inaoka H. Temporal change in IL-6 mRNA and protein expression produced by cyclic stretching of human pulmonary artery endothelial cells. Int J Mol Med 30(3):509-13, 2012.

Abstract Article

Limbourg A, von Felden J, Jagavelu K, Krishnasamy K, Napp LC, Kapopara PR, Gaestel M, Schieffer B, Bauersachs J, Limbourg FP, Bavendiek U. MAP-kinase activated protein kinase 2 links endothelial activation and monocyte/macrophage recruitment in arteriogenesis. PLoS One 10(10):e0138542, 2015.

Abstract Article

Liu WF, Nelson CM, Tan JL, Chen CS. Cadherins, RhoA, and Rac1 are differentially required for stretch-mediated proliferation in endothelial versus smooth muscle cells. Circ Res 101(5):e44-e52, 2007.

Abstract Article

Mascarenhas JB, Tchourbanov AY, Fan H, Danilov SM, Wang T, Garcia JG. Mechanical stress and single nucleotide variants regulate alternative splicing of the MYLK gene. Am J Respir Cell Mol Biol 56(1):29-37, 2017. doi: 10.1165/rcmb.2016-0053OC.

Abstract Article

Michalick L, Erfinanda L, Weichelt U, van der Giet M, Liedtke W, Kuebler WM. Transient receptor potential vanilloid 4 and serum glucocorticoid-regulated kinase 1 are critical mediators of lung injury in overventilated mice in vivo. Anesthesiology 126(2):300-311, 2017.

Abstract Article

Mitra S, Wade MS, Sun X, Moldobaeva N, Flores C, Ma SF, Zhang W, Garcia JG, Jacobson JR. GADD45a promoter regulation by a functional genetic variant associated with acute lung injury. PLoS One 9(6):e100169, 2014.

Abstract Article

Moldobaeva A, Rentsendorj O, Jenkins J, Wagner EM. Nitric oxide synthase promotes distension-induced tracheal venular leukocyte adherence. PLoS One 9(9):e106092, 2014.

Abstract Article

Nonas S, Birukova AA, Fu P, Xing J, Chatchavalvanich S, Bochkov VN, Leitinger N, Garcia JG, Birukov KG. Oxidized phospholipids reduce ventilator-induced vascular leak and inflammation in vivo. Crit Care 12(1):R27, 2008.

Abstract Article

O'Donnell JJ 3rd, Birukova AA, Beyer EC, Birukov KG. Gap junction protein connexin43 exacerbates lung vascular permeability. PLoS One 9(6):e100931, 2014.

Abstract Article

Shikata Y, Rios A, Kawkitinarong K, DePaola N, Garcia JG, Birukov KG. Differential effects of shear stress and cyclic stretch on focal adhesion remodeling, site-specific FAK phosphorylation, and small GTPases in human lung endothelial cell. Experimental Cell Research 304(1):40-49, 2005.

Abstract Article

Sun X, Elangovan VR, Mapes B, Camp SM, Sammani S, Saadat L, Ceco E, Ma SF, Flores C, MacDougall MS, Quijada H, Liu B, Kempf CL, Wang T, Chiang ET, Garcia JG. The NAMPT promoter is regulated by mechanical stress, signal transducer and activator of transcription 5, and acute respiratory distress syndrome-associated genetic variants. Am J Respir Cell Mol Biol 51(5):660-7, 2014.

Abstract Article

Tian Y, Gawlak G, O'Donnell JJ 3rd, Mambetsariev I, Birukova AA. Modulation of endothelial inflammation by low and high magnitude cyclic stretch. PLoS One 11(4):e0153387, 2016.

Abstract Article

Tirlapur N, O'Dea K, Soni S, Davies R, Sooranna S, Johnson M, Wilson M, Takata M. Pathological stretch of endothelial cells activates marginated monocytes to release microvesicles in an in vitro model of ventilator-induced lung injury [abstract]. American Journal of Respiratory and Critical Care Medicine 195:A4780, 2017.

Abstract Article

Vion AC, Birukova AA, Boulanger CM, Birukov KG. Mechanical forces stimulate endothelial microparticle generation via caspase-dependent apoptosis-independent mechanism. Pulm Circ 3(1):95-9, 2013.

Abstract Article

Wang Y, Xu CF, Liu YJ, Mao YF, Lv Z, Li SY, Zhu XY, Jiang L. Salidroside attenuates ventilation induced lung injury via SIRT1-dependent inhibition of NLRP3 inflammasome. Cell Physiol Biochem 42(1):34-43, 2017.

Abstract Article

Wedgwood S, Devol JM, Grobe A, Benavidez E, Azakie A, Fineman JR, Black SM. Fibroblast growth factor-2 expression is altered in lambs with increased pulmonary blood flow and pulmonary hypertension. Pediatr Res 61(1):32-36, 2007.

Abstract Article

Wolfson RK, Mapes B, Garcia JG. Excessive mechanical stress increases HMGB1 expression in human lung microvascular endothelial cells via STAT3. Microvasc Res 92:50-5, 2014.

Abstract Article

OTHER ENDOTHELIAL CELLS

Freese C, Schreiner D, Anspach L, Bantz C, Maskos M, Unger RE, Kirkpatrick CJ. In vitro investigation of silica nanoparticle uptake into human endothelial cells under physiological cyclic stretch. Part Fibre Toxicol 11:68, 2014.

Abstract Article

Hierck BP, Van der Heiden K, Alkemade FE, Van de Pas S, Van Thienen JV, Groenendijk BC, Bax WH, Van der Laarse A, Deruiter MC, Horrevoets AJ, Poelmann RE. Primary cilia sensitize endothelial cells for fluid shear stress. Dev Dyn 237(3):725-35, 2008.

Abstract Article

Milkiewicz M, Doyle JL, Fudalewski T, Ispanovic E, Aghasi M, Haas TL. HIF-1α and HIF-2α play a central role in stretch-induced but not shear-stress-induced angiogenesis in rat skeletal muscle. J Physiol 583(Pt 2):753-766, 2007.

Abstract Article

Milkiewicz M, Mohammadzadeh F, Ispanovic E, Gee E, Haas TL. Static strain stimulates expression of matrix metalloproteinase-2 and VEGF in microvascular endothelium via JNK- and ERK-dependent pathways. J Cell Biochem 100(3):750-761, 2007.

Abstract Article

Suzuma I, Hata Y, Clermont A, Pokras F, Rook SL, Suzuma K, Feener EP, Aiello L. Cyclic stretch and hypertension induce retinal expression of vascular endothelial growth factor and vascular endothelial growth factor receptor–2: potential mechanisms for exacerbation of diabetic retinopathy by hypertension. Diabetes 50:444–454, 2001.

Abstract Article

Vollmer T, Hinse D, Kleesiek K, Dreier J. Interactions between endocarditis-derived Streptococcus gallolyticus subsp. gallolyticus isolates and human endothelial cells. BMC Microbiol 10:78, 2010.

Abstract Article

Wang Z, do Carmo JM, Aberdein N, Fang T, Hall JE. The role of TRPC6 channels in glomerular capillary endothelial cell injury induced by mechanic stretch and high glucose. The FASEB Journal 31(1 Supplement):1031-4, 2017.

Abstract Article

Yun S, Dardik A, Haga M, Yamashita A, Yamaguchi S, Koh Y, Madri JA, Sumpio BE. Transcription factor Sp1 phosphorylation induced by shear stress inhibits membrane type 1-matrix metalloproteinase expression in endothelium. J Biol Chem 277(38):34808-34814, 2002.

Abstract Article