Kidney

Alexander LD, Alagarsamy S, Douglas JG. Cyclic stretch-induced cPLA2 mediates ERK 1/2 signaling in rabbit proximal tubule cells. Kidney International 65(2):551-563, 2004.

Abstract Article

Barutta F, Pinach S, Giunti S, Vittone F, Forbes JM, Chiarle R, Arnstein M, Perin PC, Camussi G, Cooper ME, Gruden G. Heat shock protein expression in diabetic nephropathy. Am J Physiol Renal Physiol 295(6):F1817-F1824, 2008.

Abstract Article

Burger D, Thibodeau JF, Holterman CE, Burns KD, Touyz RM, Kennedy CR. Urinary podocyte microparticles identify prealbuminuric diabetic glomerular injury. J Am Soc Nephrol 25(7):1401-7, 2014.

Abstract Article

Carey RM, McGrath HE, Pentz ES, Gomez RA, Barrett PQ. Biomechanical coupling in renin-releasing cells. J Clin Invest 100(6):1566-1574, 1997.

Abstract Article

Delimont D, Dufek BM, Meehan DT, Zallocchi M, Gratton MA, Phillips G, Cosgrove D. Laminin α2-mediated focal adhesion kinase activation triggers Alport glomerular pathogenesis. PLoS One 9(6):e99083, 2014.

Abstract Article

Diamond JR, Kreisberg R, Evans R, Nguyen TA, Ricardo SD. Regulation of proximal tubular osteopontin in experimental hydronephrosis in the rat. Kidney International 54(5):1501-1509, 1998.

Abstract Article

Durvasula RV, Petermann AT, Hiromura K, Blonski M, Pippin J, Mundel P, Pichler R, Griffin S, Couser WG, Shankland SJ. Activation of a local tissue angiotensin system in podocytes by mechanical strain. Kidney International 65(1):30-39, 2004.

Abstract Article

Durvasula RV, Shankland SJ. Mechanical strain increases SPARC levels in podocytes: implications for glomerulosclerosis. Am J Physiol Renal Physiol 289(3):F577-F584, 2005.

Abstract Article

El Chaar M, Attia E, Chen J, Hannafin J, Poppas DP, Felsen D. Cyclooxygenase-2 inhibitor decreases extracellular matrix synthesis in stretched renal fibroblasts. Nephron Exp Nephrol 100(4):e150-155, 2005.

Abstract Article

Giunti S, Pinach S, Arnaldi L, Viberti G, Perin PC, Camussi G, Gruden G. The MCP-1/CCR2 system has direct proinflammatory effects in human mesangial cells. Kidney Int 69(5):856-863, 2006.

Abstract Article

Hegarty NJ, Watson RW, Young LS, O'Neill AJ, Brady HR, Fitzpatrick JM. Cytoprotective effects of nitrates in a cellular model of hydronephrosis. Kidney International 62(1):70-77, 2002.

Abstract Article

Kiley SC, Chevalier RL. Species differences in renal Src activity direct EGF receptor regulation in life or death response to EGF. Am J Physiol Renal Physiol 293(3):F895-F903, 2007.

Abstract Article

Kiley SC, Thornhill BA, Tang SS, Ingelfinger JR, Chevalier RL. Growth factor-mediated phosphorylation of proapoptotic BAD reduces tubule cell death in vitro and in vivo. Kidney International 63(1):33-42, 2003.

Abstract Article

Lee JS, Lim JY, Kim J. Mechanical stretch induces angiotensinogen expression through PARP1 activation in kidney proximal tubular cells. In Vitro Cell Dev Biol Anim 51(1):72-8, 2015.

Abstract Article

Li D, Lu Z, Jia J, Zheng Z, Lin S. Changes in microRNAs associated with podocytic adhesion damage under mechanical stress. J Renin Angiotensin Aldosterone Syst 14(2):97-102, 2013.

Abstract Article

Maier S, Lutz R, Gelman L, Sarasa-Renedo A, Schenk S, Grashoff C, Chiquet M. Tenascin-C induction by cyclic strain requires integrin-linked kinase. Biochim Biophys Acta 1783(6):1150-1162, 2008.

Abstract Article

Martineau LC, McVeigh LI, Jasmin BJ, Kennedy CR. p38 MAP kinase mediates mechanically induced COX-2 and PG EP4 receptor expression in podocytes: implications for the actin cytoskeleton. Am J Physiol Renal Physiol 286(4):F693-F701, 2004.

Abstract Article

Miyajima A, Chen J, Lawrence C, Ledbetter S, Soslow RA, Stern J, Jha S, Pigato J, Lemer ML, Poppas DP, Vaughan ED, Felsen D. Antibody to transforming growth factor- ameliorates tubular apoptosis in unilateral ureteral obstruction. Kidney International 58(6):2301-2313, 2000.

Abstract Article

Miyajima A, Chen J, Poppas DP, Vaughan ED, Felsen D. Role of nitric oxide in renal tubular apoptosis of unilateral ureteral obstruction. Kidney International 59(4):1290-1303, 2001.

Abstract Article

Morgera S, Schlenstedt J, Hambach P, Giessing M, Deger S, Hocher B, Neumayer HH. Combined ETA/ETB receptor blockade of human peritoneal mesothelial cells inhibits collagen I RNA synthesis. Kidney International 64:2033–2040, 2003.

Abstract Article

Nguyen HT, Bride SH, Badawy AB, Adam RM, Lin J, Orsola A, Guthrie PD, Freeman MR, Peters CA. Heparin-binding EGF-like growth factor is up-regulated in the obstructed kidney in a cell- and region-specific manner and acts to inhibit apoptosis. American Journal of Pathology 156:889-898, 2000.

Abstract Article

Orton DJ, Doucette AA, Maksym GN, Maclellan DL. Proteomic analysis of rat proximal tubule cells following stretch-induced apoptosis in an in vitro model of kidney obstruction. J Proteomics 100:125-35, 2014.

Abstract Article

Ostergaard M, Christensen M, Nilsson L, Carlsen I, Frøkiær J, Nørregaard R. ROS dependence of cyclooxygenase-2 induction in rats subjected to unilateral ureteral obstruction. Am J Physiol Renal Physiol 306(2):F259-70, 2014.

Abstract Article

Petermann AT, Hiromura K, Blonski M, Pippin J, Monkawa T, Durvasula R, Couser WG, Shankland SJ. Mechanical stress reduces podocyte proliferation in vitro. Kidney International 61(1):40-50, 2002.

Abstract Article

Petermann AT, Pippin J, Durvasula R, Pichler R, Hiromura K, Monkawa T, Couser WG, Shankland SJ. Mechanical stretch induces podocyte hypertrophy in vitro. Kidney International 67(1):157-166, 2005.

Abstract Article

26. Ricardo SD, Ding G, Eufemio M, Diamond JR. Antioxidant expression in experimental hydronephrosis: role of mechanical stretch and growth factors. Am J Physiol Renal Physiol 272:F789-F798, 1997.

Abstract Article

Ricardo SD, Franzoni DF, Roesener CD, Crisman JM, Diamond JR. Angiotensinogen and AT(1) antisense inhibition of osteopontin translation in rat proximal tubular cells. Am J Physiol Renal Physiol 278(5):F708-F716, 2000.

Abstract Article

Ryan MJ, Black TA, Gross KW, Hajduczok G. Cyclic mechanical distension regulates renin gene transcription in As4.1 cells. Am J Physiol Endocrinol Metab 279(4):E830-E837, 2000.

Abstract Article

Ryan MJ, Gross KW, Hajduczok G. Calcium-dependent activation of phospholipase C by mechanical distension in renin-expressing As4.1 cells. Am J Physiol Endocrinol Metab 279(4):E823-E829, 2000.

Abstract Article

Sato M, Muragaki Y, Saika S, Roberts AB, Ooshima A. Targeted disruption of TGF-beta1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction. J Clin Invest 112(10):1486-1494, 2003.

Abstract Article

Speight P, Kofler M, Szászi K, Kapus A. Context-dependent switch in chemo/mechanotransduction via multilevel crosstalk among cytoskeleton-regulated MRTF and TAZ and TGFβ-regulated Smad3. Nat Commun 7:11642, 2016.

Abstract Article

Sussman AN, Sun T, Krofft RM, Durvasula RV. SPARC accelerates disease progression in experimental crescentic glomerulonephritis. Am J Pathol 174(5):1827-1836, 2009.

Abstract Article

Tanner GA, McQuillan PF, Maxwell MR, Keck JK, McAteer JA. An in vitro test of the cell stretch-proliferation hypothesis of renal cyst enlargement. J Am Soc Nephrol 6(4):1230-1241, 1995.

Abstract Article

Wang Z, do Carmo JM, Aberdein N, Fang T, Hall JE. The role of TRPC6 channels in glomerular capillary endothelial cell injury induced by mechanic stretch and high glucose. The FASEB Journal 31(1 Supplement):1031-4, 2017.

Abstract Article

MESANGIAL CELLS

Akai Y, Homma T, Burns KD, Yasuda T, Badr KF, Harris RC. Mechanical stretch/relaxation of cultured rat mesangial cells induces protooncogenes and cyclooxygenase. Am J Physiol Cell Physiol 267(2):C482-C490, 1994.

Abstract Article

Barutta F, Pinach S, Giunti S, Vittone F, Forbes JM, Chiarle R, Arnstein M, Perin PC, Camussi G, Cooper ME, Gruden G. Heat shock protein expression in diabetic nephropathy. Am J Physiol Renal Physiol 295(6):F1817-F1824, 2008.

Abstract Article

Chen G, Chen X, Sukumar A, Gao B, Curley J, Schnaper HW, Ingram AJ, Krepinsky JC. TGFβ receptor I transactivation mediates stretch-induced Pak1 activation and CTGF upregulation in mesangial cells. J Cell Sci 126(Pt 16):3697-712, 2013.

Abstract Article

Clarkson MR, Murphy M, Gupta S, Lambe T, Mackenzie HS, Godson C, Martin F, Brady HR. High glucose-altered gene expression in mesangial cells. Actin-regulatory protein gene expression is triggered by oxidative stress and cytoskeletal disassembly. J Biol Chem 277(12):9707-9712, 2002.

Abstract Article

Cortes P, Zhao X, Riser BL, Narins RG. Role of glomerular mechanical strain in the pathogenesis of diabetic nephropathy. Kidney International 51(1):57-68, 1997.

Abstract Article

Dlugosz JA, Munk S, Kapor-Drezgic J, Goldberg HJ, Fantus IG, Scholey JW, Whiteside CI. Stretch-induced mesangial cell ERK1/ERK2 activation is enhanced in high glucose by decreased dephosphorylation. Am J Physiol Renal Physiol 279:688-697, 2000.

Abstract Article

Giunti S, Pinach S, Arnaldi L, Viberti G, Perin PC, Camussi G, Gruden G. The MCP-1/CCR2 system has direct proinflammatory effects in human mesangial cells. Kidney Int 69(5):856-863, 2006.

Abstract Article

Gruden G, Araf S, Zonca S, Burt D, Thomas S, Gnudi L, Viberti G. IGF-I induces vascular endothelial growth factor in human mesangial cells via a Src-dependent mechanism. Kidney International 63(4):1249-1255, 2003.

Abstract Article

Gruden G, Setti G, Hayward A, Sugden D, Duggan S, Burt D, Buckingham RE, Gnudi L, Viberti G. Mechanical stretch induces monocyte chemoattractant activity via an NF-kappaB-dependent monocyte chemoattractant protein-1-mediated pathway in human mesangial cells: inhibition by rosiglitazone. J Am Soc Nephrol 16(3):688-96, 2005.

Abstract Article

Gruden G, Thomas S, Burt D, Lane S, Chusney G, Sacks S, Viberti G. Mechanical stretch induces vascular permeability factor in human mesangial cells: mechanisms of signal transduction. Proc Natl Acad Sci U S A 94(22):12112-12116, 1997.

Abstract Article

Gruden G, Thomas S, Burt D, Zhou W, Chusney G, Gnudi L, Viberti G. Interaction of angiotensin II and mechanical stretch on vascular endothelial growth factor production by human mesangial cells. J Am Soc Nephrol 10(4):730-737, 1999.

Abstract Article

Hayashi Y, Katoh T, Asano K, Onozaki A, Sakurai K, Asahi K, Nakayama M, Watanabe T. Mechanical stretch down-regulates expression of the Smad6 gene in cultured rat mesangial cells. Clin Exp Nephrol 16(5):690-696, 2012.

Abstract Article

Hirakata M, Kaname S, Chung UG, Joki N, Hori Y, Noda M, Takuwa Y, Okazaki T, Fujita T, Katoh T, Kurokawa K. Tyrosine kinase dependent expression of TGF- induced by stretch in mesangial cells. Kidney Int 51(4):1028-36, 1997.

Abstract Article

Homma T, Akai Y, Burns KD, Harris RC. Activation of S6 kinase by repeated cycles of stretching and relaxation in rat glomerular mesangial cells. Evidence for involvement of protein kinase C. J Biol Chem 267(32):23129-23135, 1992.

Abstract Article

Hori Y, Katoh T, Hirakata M, Joki N, Kaname S, Fukagawa M, Okuda T, Ohashi H, Fujita T, Miyazono K, Kurokawa K. Anti-latent TGF- binding protein-1 antibody or synthetic oligopeptides inhibit extracellular matrix expression induced by stretch in cultured rat mesangial cells. Kidney Int 53:1616-1625, 1998.

Abstract Article

Ingram AJ, James L, Cai L, Thai K, Ly H, Scholey JW. NO inhibits stretch-induced MAPK activity by cytoskeletal disruption. J Biol Chem 275(51):40301-40306, 2000.

Abstract Article

Ingram AJ, James L, Ly H, Thai K, Cai L, Scholey JW. Nitric oxide modulates stretch activation of mitogen-activated protein kinases in mesangial cells. Kidney International 58(3):1067-1077, 2000.

Abstract Article

Ingram AJ, James L, Ly H, Thai K, Scholey JW. Stretch activation of Jun N-terminal kinase/stress-activated protein kinase in mesangial cells. Kidney International 58(4):1431-1439, 2000.

Abstract Article

Ingram AJ, James L, Thai K, Ly H, Cai L, Scholey JW. Nitric oxide modulates mechanical strain-induced activation of p38 MAPK in mesangial cells. Am J Physiol Renal Physiol 279(2):F243-F251, 2000.

Abstract Article

Ingram AJ, Ly H, Thai K, Kang M, Scholey JW. Activation of mesangial cell signaling cascades in response to mechanical strain. Kidney International 55(2):476-485, 1999.

Abstract Article

Ingram AJ, Ly H, Thai K, Kang MJ, Scholey JW. Mesangial cell signaling cascades in response to mechanical strain and glucose. Kidney International 56(5):1721-1728, 1999.

Abstract Article

Krepinsky J, Ingram AJ, James L, Ly H, Thai K, Cattran DC, Miller JA, Scholey JW. 17beta-Estradiol modulates mechanical strain-induced MAPK activation in mesangial cells. J Biol Chem 277(11):9387-9394, 2002.

Abstract Article

Krepinsky JC, Ingram AJ, Tang D, Wu D, Liu L, Scholey JW. Nitric oxide inhibits stretch-induced MAPK activation in mesangial cells through RhoA inactivation. J Am Soc Nephrol 14(11):2790-2800, 2003.

Abstract Article

Krepinsky JC, Li Y, Chang Y, Liu L, Peng F, Wu D, Tang D, Scholey J, Ingram AJ. Akt mediates mechanical strain-induced collagen production by mesangial cells. J Am Soc Nephrol 16(6):1661-1672, 2005.

Abstract Article

McMahon R, Murphy M, Clarkson M, Taal M, Mackenzie HS, Godson C, Martin F, Brady HR. IHG-2, a mesangial cell gene induced by high glucose, is human gremlin. Regulation by extracellular glucose concentration, cyclic mechanical strain, and transforming growth factor-beta1. J Biol Chem 275(14):9901-9904, 2000.

Abstract Article

Peng F, Wu D, Ingram AJ, Zhang B, Gao B, Krepinsky JC. RhoA activation in mesangial cells by mechanical strain depends on caveolae and caveolin-1 interaction. J Am Soc Nephrol 18(1):189-198, 2007.

Abstract Article

Riser BL, Cortes P, Yee J, Sharba AK, Asano K, Rodriguez-Barbero A, Narins RG. Mechanical strain- and high glucose-induced alterations in mesangial cell collagen metabolism: role of TGF-beta. J Am Soc Nephrol 9:827-836, 1998.

Abstract Article

Riser BL, Denichilo M, Cortes P, Baker C, Grondin JM, Yee J, Narins RG. Regulation of connective tissue growth factor activity in cultured rat mesangial cells and its expression in experimental diabetic glomerulosclerosis. J Am Soc Nephrol 11(1):25-38, 2000.

Abstract Article

Riser BL, Ladson-Wofford S, Sharba A, Cortes P, Drake K, Guerin CJ, Yee J, Choi ME, Segarini PR, Narins RG. TGF-beta receptor expression and binding in rat mesangial cells: modulation by glucose and cyclic mechanical strain. Kidney International 56(2):428-439, 1999.

Abstract Article

Riser BL, Varani J, Cortes P, Yee J, Dame M, Sharba AK. Cyclic stretching of mesangial cells up-regulates intercellular adhesion molecule-1 and leukocyte adherence: a possible new mechanism for glomerulosclerosis. Am J Pathol 158(1):11-17, 2001.

Abstract Article

Yasuda T, Kondo S, Homma T, Harris RC. Regulation of extracellular matrix by mechanical stress in rat glomerular mesangial cells. J Clin Invest 98(9):1991-2000, 1996.

Abstract Article

Yasuda T, Kondo S, Owada S, Ishida M, Harris RC. Integrins and the cytoskeleton: focal adhesion kinase and paxillin. Nephrol Dial Transplant 14(Suppl 1):58-60, 1999.

Abstract Article

Yatabe J, Sanada H, Yatabe MS, Hashimoto S, Yoneda M, Felder RA, Jose PA, Watanabe T. Angiotensin II type 1 receptor blocker attenuates the activation of ERK and NADPH oxidase by mechanical strain in mesangial cells in the absence of angiotensin II. Am J Physiol Renal Physiol 296(5):F1052-F1060, 2009.

Abstract Article

RENAL EPITHELIAL CELLS

Cachat F, Lange-Sperandio B, Chang AY, Kiley SC, Thornhill BA, Forbes MS, Chevalier RL. Ureteral obstruction in neonatal mice elicits segment-specific tubular cell responses leading to nephron loss. Kidney International 63(2):564-575, 2003.

Abstract Article

Kiley SC, Thornhill BA, Belyea BC, Neale K, Forbes MS, Luetteke NC, Lee DC, Chevalier RL. Epidermal growth factor potentiates renal cell death in hydronephrotic neonatal mice, but cell survival in rats. Kidney International 68(2):504-514, 2005.  

Abstract Article

Nguyen HT, Hsieh MH, Gaborro A, Tinloy B, Phillips C, Adam RM. JNK/SAPK and p38 SAPK-2 mediate mechanical stretch-induced apoptosis via caspase-3 and -9 in NRK-52E renal epithelial cells. Nephron Exp Nephrol 102(2):e49-61, 2006.  

Abstract Article

Power RE, Doyle BT, Higgins D, Brady HR, Fitzpatrick JM, Watson RW. Mechanical deformation induced apoptosis in human proximal renal tubular epithelial cells is caspase dependent. J Urol 171(1):45761, 2004.  

Abstract Article

Sato M, Muragaki Y, Saika S, Roberts AB, Ooshima A. Targeted disruption of TGF-beta1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction. J Clin Invest 112(10):1486-1494, 2003.

Abstract Article