Agarwal S, Long P, Seyedain A, Piesco N, Shree A, Gassner R. A central role for the nuclear factor-B pathway in anti-inflammatory and proinflammatory actions of mechanical strain. FASEB J 17(8):899-901, 2003.
Bolcato-Bellemin AL, Elkaim R, Abehsera A, Fausser JL, Haikel H, Tenenbaum H. Expression of mRNAs encoding for and integrin subunits, MMPs, and TIMPs in stretched human periodontal ligament and gingival fibroblasts. J Dent Res 79(9):1712-1716, 2000.
Chang M, Lin H, Luo M, Wang J, Han G. Integrated miRNA and mRNA expression profiling of tension force-induced bone formation in periodontal ligament cells. In Vitro Cell Dev Biol Anim. 51(8):797-807, 2015.
Chen YJ, Jeng JH, Chang HH, Huang MY, Tsai FF, Yao CC. Differential regulation of collagen, lysyl oxidase and MMP-2 in human periodontal ligament cells by low- and high-level mechanical stretching. J Periodontal Res 48(4):466-74, 2013.
Chen Y, Mohammed A, Oubaidin M, Evans CA, Zhou X, Luan X, Diekwisch TG, Atsawasuwan P. Cyclic stretch and compression forces alter microRNA-29 expression of human periodontal ligament cells. Gene 566(1):13-7, 2015.
Chiba M, Mitani H. Cytoskeletal changes and the system of regulation of alkaline phosphatase activity in human periodontal ligament cells induced by mechanical stress. Cell Biochemistry and Function 22(4):249-256, 2004.
Cho JH, Lee SK, Lee JW, Kim EC. The role of heme oxygenase-1 in mechanical stress- and lipopolysaccharide-induced osteogenic differentiation in human periodontal ligament cells. Angle Orthod 80(4):552-559, 2010.
Doi T, Ohno S, Tanimoto K, Honda K, Tanaka N, Ohno-Nakahara M, Yoneno K, Suzuki A, Nakatani Y, Ueki M, Tanne K. Mechanical stimuli enhances the expression of RGD-CAP/beta ig-h3 in the periodontal ligament. Archives of Oral Biology 48(8):573-579, 2003.
Duarte WR, Mikuni-Takagaki Y, Kawase T, Limura T, Oida S, Ohya K, Takenaga K, Ishikawa L, Kasugai S. Effects of mechanical stress on the mRNA expression of S100A4 and cytoskeletal components by periodontal ligament cells. J Med Dent Sci 46(3):117-122, 1999.
Enokiya Y, Hashimoto S, Muramatsu T, Jung HS, Tazaki M, Inoue T, Abiko Y, Shimono M. Effect of stretching stress on gene transcription related to early-phase differentiation in rat periodontal ligament cells. Bull Tokyo Dent Coll 51(3):129-137, 2010.
Han Y, Pan J, Wang X, Qi Y, Wang S, Yan Z. Cyclic strain promotes migration and proliferation of human periodontal ligament cell via PI3K signaling pathway. Cellular and Molecular Bioengineering 3(4):369-375, 2010.
Huelter-Hassler D, Tomakidi P, Steinberg T, Jung BA. Orthodontic strain affects the Hippo-pathway effector YAP concomitant with proliferation in human periodontal ligament fibroblasts. Eur J Orthod 2017 Mar 17. doi: 10.1093/ejo/cjx012. [Epub ahead of print]
Jacobs C, Walter C, Ziebart T, Dirks I, Schramm S, Grimm S, Krieger E, Wehrbein H. Mechanical loading influences the effects of bisphosphonates on human periodontal ligament fibroblasts. Clin Oral Investig 19(3):699-708, 2015.
Jacobs C, Walter C, Ziebart T, Grimm S, Meila D, Krieger E, Wehrbein H. Induction of IL-6 and MMP-8 in human periodontal fibroblasts by static tensile strain. Clin Oral Investig 18(3):901-8, 2014.
Kanzaki H, Chiba M, Sato A, Miyagawa A, Arai K, Nukatsuka S, Mitani H. Cyclical tensile force on periodontal ligament cells inhibits osteoclastogenesis through OPG induction. J Dent Res 85(5):457-462, 2006.
Kikuiri T, Hasegawa T, Yoshimura Y, Shirakawa T, Oguchi H. Cyclic tension force activates nitric oxide production in cultured human periodontal ligament cells. J Periodontol 71(4):533-539, 2000.
Kim HJ, Choi YS, Jeong MJ, KimBO, Lim SH, Kim DK, Kim CK, Park JC. Expression of UNCL during development of periodontal tissue and response of periodontal ligament fibroblasts to mechanical stress in vivo and in vitro. Cell Tissue Res 327(1):25-31, 2007.
Kim JH, Kang MS, Eltohamy M, Kim TH, Kim HW. Dynamic mechanical and nanofibrous topological combinatory cues designed for periodontal ligament engineering. PLoS One 11(3):e0149967, 2016.
Kimoto S, Matsuzawa M, Matsubara S, Komatsu T, Uchimura N, Kawase T, Saito S. Cytokine secretion of periodontal ligament fibroblasts derived from human deciduous teeth: effect of mechanical stress on the secretion of transforming growth factor-1 and macrophage colony stimulating factor. J Periodontal Res 34(5):235-243, 1999.
Lee SI, Park KH, Kim SJ, Kang YG, Lee YM, Kim EC. Mechanical stress-activated immune response genes via Sirtuin 1 expression in human periodontal ligament cells. Clin Exp Immunol 168(1):113-24, 2012.
Liu J, Li Q, Liu S, Gao J, Qin W, Song Y, Jin Z. Periodontal ligament stem cells in the periodontitis microenvironment are sensitive to static mechanical strain. Stem Cells Int 2017:1380851, 2017.
Liu M, Dai J, Lin Y, Yang L, Dong H, Li Y, Ding Y, Duan Y. Effect of the cyclic stretch on the expression of osteogenesis genes in human periodontal ligament cells. Gene 491(2):187-193, 2012.
Long P, Hu J, Piesco N, Buckley M, Agarwal S. Low magnitude of tensile strain inhibits IL-1beta-dependent induction of pro-inflammatory cytokines and induces synthesis of IL-10 in human periodontal ligament cells in vitro. J Dent Res 80(5):1416-1420, 2001.
Long P, Liu F, Piesco NP, Kapur R, Agarwal S. Signaling by mechanical strain involves transcriptional regulation of proinflammatory genes in human periodontal ligament cells in vitro. Bone 30(4):547-552, 2002.
Matsuda N, Yokoyama K, Takeshita S, Watanabe M. Role of epidermal growth factor and its receptor in mechanical stress-induced differentiation of human periodontal ligament cells in vitro. Arch Oral Biol 43(12):987-997, 1998.
Miura S, Yamaguchi M, Shimizu N, Abiko Y. Mechanical stress enhances expression and production of plasminogen activator in aging human periodontal ligament cells. Mechanisms of Ageing and Development 112(3):217-231, 2000.
Myokai F, Oyama M, Nishimura F, Ohira T, Yamamoto T, Arai H, Takashiba S, Murayama Y. Unique genes induced by mechanical stress in periodontal ligament cells. J Periodontal Res 38(3):255-261, 2003.
Nogueira AV, Nokhbehsaim M, Eick S, Bourauel C, Jäger A, Jepsen S, Cirelli JA, Deschner J. Regulation of visfatin by microbial and biomechanical signals in PDL cells. Clin Oral Investig 18(1):171-8, 2014.
Nokhbehsaim M, Deschner B, Winter J, Bourauel C, Jäger A, Jepsen S, Deschner J. Anti-inflammatory effects of EMD in the presence of biomechanical loading and interleukin-1β in vitro. Clin Oral Investig 16(1):275-283, 2012.
Nokhbehsaim M, Deschner B, Winter J, Bourauel C, Rath B, Jäger A, Jepsen S, Deschner J. Interactions of regenerative, inflammatory and biomechanical signals on bone morphogenetic protein-2 in periodontal ligament cells. J Periodontal Res 46(3):374-381, 2011.
Nokhbehsaim M, Deschner B, Winter J, Reimann S, Bourauel C, Jepsen S, Jäger A, Deschner J. Contribution of orthodontic load to inflammation-mediated periodontal destruction. J Orofac Orthop 71(6):390-402, 2010.
Ohzeki K, Yamaguchi M, Shimizu N, Abiko Y. Effect of cellular aging on the induction of cyclooxygenase-2 by mechanical stress in human periodontal ligament cells. Mechanisms of Ageing and Development 108(2):151-163, 1999.
Ozaki S, Kaneko S, Podyma-Inoue KA, Yanagishita M, Soma K. Modulation of extracellular matrix synthesis and alkaline phosphatase activity of periodontal ligament cells by mechanical stress. J Periodontal Res 40(2):110-117, 2005.
Ozawa Y, Shimizu N, Abiko Y. Low-energy diode laser irradiation reduced plasminogen activator activity in human periodontal ligament cells. Lasers Surg Med 21(5):456-463, 1997.
Pan J, Wang T, Wang L, Chen W, Song M. Cyclic strain-induced cytoskeletal rearrangement of human periodontal ligament cells via the Rho signaling pathway. PLoS One 9(3):e91580, 2014.
Rosselli-Murai LK, Almeida LO, Zagni C, Galindo-Moreno P, Padial-Molina M, Volk SL, Murai MJ, Rios HF, Squarize CH, Castilho RM. Periostin responds to mechanical stress and tension by activating the MTOR signaling pathway. PLoS One 8(12):e83580, 2013.
Saeki Y, Ohara A, Nishikawa M, Yamamoto T, Yamamoto G. The presence of arachidonic acid-activated K+ channel, TREK-1, in human periodontal ligament fibroblasts. Drug Metab Rev 39(2-3):457-465, 2007.
Saminathan A, Vinoth KJ, Wescott DC, Pinkerton MN, Milne TJ, Cao T, Meikle MC. The effect of cyclic mechanical strain on the expression of adhesion-related genes by periodontal ligament cells in two-dimensional culture. J Periodontal Res 47(2):212-221, 2012.
Saminathan A, Vinoth KJ, Low HH, Cao T, Meikle MC. Engineering three-dimensional constructs of the periodontal ligament in hyaluronan-gelatin hydrogel films and a mechanically active environment. J Periodontal Res 2013 Apr 15.
Shen T, Qiu L, Chang H, Yang Y, Jian C, Xiong J, Zhou J, Dong S. Cyclic tension promotes osteogenic differentiation in human periodontal ligament stem cells. Int J Clin Exp Pathol 7(11):7872-80, 2014.
Shimizu N, Yamaguchi M, Uesu K, Goseki T, Abiko Y. Stimulation of prostaglandin E2 and interleukin-1production from old rat periodontal ligament cells subjected to mechanical stress. J Gerontol A Biol Sci Med Sci 55(10):B489-B495, 2000.
Sun C, Liu F, Cen S, Chen L, Wang Y, Sun H, Deng H, Hu R. Tensile strength suppresses the osteogenesis of periodontal ligament cells in inflammatory microenvironments. Mol Med Rep 16(1):666-672, 2017.
Tsuji K, Uno K, Zhang GX, Tamura M. Periodontal ligament cells under intermittent tensile stress regulate mRNA expression of osteoprotegerin and tissue inhibitor of matrix metalloprotease-1 and -2. J Bone Miner Metab 22(2):94-103, 2004.
Wang L, Pan J, Wang T, Song M, Chen W. Pathological cyclic strain-induced apoptosis in human periodontal ligament cells through the RhoGDIα/caspase-3/PARP pathway. PLoS One 8(10):e75973, 2013.
Wei FL, Wang JH, Ding G, Yang SY, Li Y, Hu YJ, Wang SL. Mechanical force-induced specific microRNA expression in human periodontal ligament stem cells. Cells Tissues Organs 199(5-6):353-63, 2014.
Wen W, Chau E, Jackson-Boeters L, Elliott C, Daley TD, Hamilton DW. TGF-beta1 and FAK regulate periostin expression in PDL fibroblasts. J Dent Res 89(12):1439-1443, 2010.
Wescott DC, Pinkerton MN, Gaffey BJ, Beggs KT, Milne TJ, Meikle MC. Osteogenic gene expression by human periodontal ligament cells under cyclic tension. J Dent Res 86(12):1212-1216, 2007.
Wu J, Song M, Li T, Zhu Z, Pan J. The Rho-mDia1 signaling pathway is required for cyclic strain-induced cytoskeletal rearrangement of human periodontal ligament cells. Exp Cell Res 337(1):28-36, 2015.
Yamaguchi M, Shimizu N, Goseki T, Shibata Y, Takiguchi H, Iwasawa T, Abiko Y. Effect of different magnitudes of tension force on prostaglandin E2 production by human periodontal ligament cells. Archives of Oral Biology 39(10):877-884, 1994.
Yamaguchi M, Shimizu N, Ozawa Y, Saito K, Miura S, Takiguchi H, Iwasawa T, Abiko Y. Effect of tension-force on plasminogen activator activity from human periodontal ligament cells. J Periodontal Res 32(3):308-314, 1997.
Yamaguchi M, Shimizu N. Identification of factors mediating the decrease of alkaline phosphatase activity caused by tension-force in periodontal ligament cells. General Pharmacology 25(6):1229-1235, 1994.
Yamaguchi N, Chiba M, Mitani H. The induction of c-fos mRNA expression by mechanical stress in human periodontal ligament cells. Archives of Oral Biology 47(6):465-471, 2002.
Yamashiro K, Myokai F, Hiratsuka K, Yamamoto T, Senoo K, Arai H, Nishimura F, Abiko Y, Takashiba S. Oligonucleotide array analysis of cyclic tension-responsive genes in human periodontal ligament fibroblasts. The International Journal of Biochemistry & Cell Biology 39(5):910-921, 2007.
Yoshino H, Morita I, Murota SI, Ishikawa I. Mechanical stress induces production of angiogenic regulators in cultured human gingival and periodontal ligament fibroblasts. J Periodontal Res 38(4):405-410, 2003.
Hannafin JA, Attia EA, Henshaw R, Warren RF, Bhargava MM. Effect of cyclic strain and plating matrix on cell proliferation and integrin expression by ligament fibroblasts. J Orthop Res 24(2):149-58, 2006.
Henshaw DR, Attia E, Bhargava M, Hannafin JA. Canine ACL fibroblast integrin expression and cell alignment in response to cyclic tensile strain in three-dimensional collagen gels. J Orthop Res 24(3):481-490, 2006.
Hsieh AH, Tsai CM, Ma QJ, Lin T, Banes AJ, Villarreal FJ, Akeson WH, Sung KL. Time-dependent increases in type-III collagen gene expression in medical collateral ligament fibroblasts under cyclic strains. J Orthop Res 18(2):220-227, 2000.
Jones BF, Wall ME, Carroll RL, Washburn S, Banes AJ. Ligament cells stretch-adapted on a microgrooved substrate increase intercellular communication in response to a mechanical stimulus. J Biomech 38(8):1653-1664, 2005.
Lee CH, Shin HJ, Cho IH, Kang YM, Kim IA, Park KD, Shin JW. Nanofiber alignment and direction of mechanical strain affect the ECM production of human ACL fibroblast. Biomaterials 26(11):1261-1270, 2005.
Lee CY, Liu X, Smith CL, Zhang X, Hsu HC, Wang DY, Luo ZP. The combined regulation of estrogen and cyclic tension on fibroblast biosynthesis derived from anterior cruciate. Matrix Biology 23(5):323-329, 2004.
Lee CY, Smith CL, Zhang X, Hsu HC, Wang DY, Luo ZP. Tensile forces attenuate estrogen-stimulated collagen synthesis in the ACL. Biochemical and Biophysical Research Communications 317:1221–1225, 2004.
Sun L, Qu L, Zhu R, Li H, Xue Y, Liu X, Fan J, Fan H. Effects of mechanical stretch on cell proliferation and matrix formation of mesenchymal stem cell and anterior cruciate ligament fibroblast. Stem Cells Int 2016:9842075, 2016.
Wang C, Xie J, Jiang J, Huang W, Chen R, Xu C, Zhang Y, Fu C, Yang L, Chen PC, Sung KL. Differential expressions of the lysyl oxidase family and matrix metalloproteinases-1, 2, 3 in posterior cruciate ligament fibroblasts after being co-cultured with synovial cells. Int Orthop 39(1):183-91, 2015.
Xie J, Wang CL, Yang W, Wang J, Chen C, Zheng L, Sung KP, Zhou X. Modulation of MMP-2 and -9 through connected pathways and growth factors is critical for extracellular matrix balance of intra-articular ligaments. J Tissue Eng Regen Med. 12(1):e550-e565. doi: 10.1002/term.2325, 2018.
Chen D, Liu Y, Yang H, Chen D, Zhang X, Fermandes JC, Chen Y. Connexin 43 promotes ossification of the posterior longitudinal ligament through activation of the ERK1/2 and p38 MAPK pathways. Cell Tissue Res 363(3):765-73, 2016.
Ewies AA, Elshafie M, Li J, Stanley A, Thompson J, Styles J, White I, Al-Azzawi F. Changes in transcription profile and cytoskeleton morphology in pelvic ligament fibroblasts in response to stretch: the effects of estradiol and levormeloxifene. Mol Hum Reprod 14(2):127-135, 2008.
Nakatani T, Marui T, Hitora T, Doita M, Nishida K, Kurosaka M. Mechanical stretching force promotes collagen synthesis by cultured cells from human ligamentum flavum via transforming growth factor-1. J Orthop Res 20(6):1380-1386, 2002.
Ning S, Chen Z, Fan D, Sun C, Zhang C, Zeng Y, Li W, Hou X, Qu X, Ma Y, Yu H. Genetic differences in osteogenic differentiation potency in the thoracic ossification of the ligamentum flavum under cyclic mechanical stress. Int J Mol Med 39(1):135-143, 2017.
Yang HS, Lu XH, Chen DY, Yuan W, Yang LL, Chen Y, He HL. Mechanical strain induces Cx43 expression in spinal ligament fibroblasts derived from patients presenting ossification of the posterior longitudinal ligament. Eur Spine J 20(9):1459-1465, 2011.
Zhang W, Wei P, Chen Y, Yang L, Jiang C, Jiang P, Chen D. Down-regulated expression of vimentin induced by mechanical stress in fibroblasts derived from patients with ossification of the posterior longitudinal ligament. Eur Spine J 23(11):2410-5, 2014.
