Uniflex® Tension

Bhatt KA, Chang EI, Warren SM, Lin SE, Bastidas N, Ghali S, Thibboneir A, Capla JM, McCarthy JG, Gurtner GC. Uniaxial mechanical strain: an in vitro correlate to distraction osteogenesis. J Surg Res 143(2):329-336, 2007.

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Boonen KJ, Langelaan ML, Polak RB, van der Schaft DW, Baaijens FP, Post MJ. Effects of a combined mechanical stimulation protocol: value for skeletal muscle tissue engineering. J Biomech 43(8):1514-1521, 2010.

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Brown JP, Finley VG, Kuo CK. Embryonic mechanical and soluble cues regulate tendon progenitor cell gene expression as a function of developmental stage and anatomical origin. J Biomech 47(1):214-22, 2014.  

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Brown JP, Galassi TV, Stoppato M, Schiele NR, Kuo CK. Comparative analysis of mesenchymal stem cell and embryonic tendon progenitor cell response to embryonic tendon biochemical and mechanical factors. Stem Cell Res Ther 6:89, 2015.  

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Dugan JM, Cartmell SH, Gough JE. Uniaxial cyclic strain of human adipose-derived mesenchymal stem cells and C2C12 myoblasts in coculture. J Tissue Eng 5:2041731414530138, 2014.

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Foolen J, Deshpande VS, Kanters FM, Baaijens FP. The influence of matrix integrity on stress-fiber remodeling in 3D. Biomaterials 33(30):7508-7518, 2012.  

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Ghosh K, Thodeti CK, Dudley AC, Mammoto A, Klagsbrun M, Ingber DE. Tumor-derived endothelial cells exhibit aberrant Rho-mediated mechanosensing and abnormal angiogenesis in vitro. Proc Natl Acad Sci U S A 105(32):11305-11310, 2008.  

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Hamilton DW, Maul TM, Vorp DA. Characterization of the response of bone marrow-derived progenitor cells to cyclic strain: implications for vascular tissue-engineering applications. Tissue Engineering 10(3-4):361-369, 2004.  

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Huri PY, Wang A, Spector AA, Grayson WL. Multistage adipose-derived stem cell myogenesis: an experimental and modeling study. Cellular and Molecular Bioengineering 7(4):497-509, 2014.

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Jones BF, Wall ME, Carroll RL, Washburn S, Banes AJ. Ligament cells stretch-adapted on a microgrooved substrate increase intercellular communication in response to a mechanical stimulus. J Biomech 38(8):16531664, 2005.  

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Juffer P, Jaspers RT, Klein-Nulend J, Bakker AD. Mechanically loaded myotubes affect osteoclast formation. Calcif Tissue Int 94(3):319-26, 2014.

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Kim JH, Kang MS, Eltohamy M, Kim TH, Kim HW. Dynamic mechanical and nanofibrous topological combinatory cues designed for periodontal ligament engineering. PLoS One 11(3):e0149967, 2016.

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Lee EL, Bendre HH, Kalmykov A, Wong JY. Surface modification of uniaxial cyclic strain cell culture platform with temperature-responsive polymer for cell sheet detachment. J Mater Chem B Mater Biol Med 3(40):7899-7902, 2015.

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Lee WC, Maul TM, Vorp DA, Rubin JP, Marra KG. Effects of uniaxial cyclic strain on adipose-derived stem cell morphology, proliferation, and differentiation. Biomech Model Mechanobiol 6(4):265-273, 2007.  

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Matheson LA, Jack FN, Maksym GN, Paul SJ, Labow RS. Characterization of the Flexcell Uniflex cyclic strain culture system with U937 macrophage-like cells. Biomaterials 27(2):226-233, 2006.  

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Matheson LA, Maksym GN, Santerre JP, Labow RS. Differential effects of uniaxial and biaxial strain on U937 macrophage-like cell morphology: Influence of extracellular matrix type proteins. J Biomed Mater Res A 81:971-981, 2007.

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Matheson LA, Maksym GN, Santerre JP, Labow RS. The functional response of U937 macrophage-like cells is modulated by extracellular matrix proteins and mechanical strain. Biochem Cell Biol 84(5):763-773, 2006.

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Rolin GL, Binda D, Tissot M, Viennet C, Saas P, Muret P, Humbert P. In vitro study of the impact of mechanical tension on the dermal fibroblast phenotype in the context of skin wound healing. J Biomech 47(14):3555-61, 2014

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Sedding DG, Hermsen J, Seay U, Eickelberg O, Kummer W, Schwencke C, Strasser RH, Tillmanns H, Braun-Dullaeus RC. Caveolin-1 facilitates mechanosensitive protein kinase B (Akt) signaling in vitro and in vivo. Circ Res 96(6):635-642, 2005.

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Sedding DG, Homann M, Seay U, Tillmanns H, Preissner KT, Braun-Dullaeus RC. Calpain counteracts mechanosensitive apoptosis of vascular smooth muscle cells in vitro and in vivo. FASEB J 22(2):579-589, 2008.  

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Sedding DG, Widmer-Teske R, Mueller A, Stieger P, Daniel JM, Gündüz D, Pullamsetti S, Nef H, Moellmann H, Troidl C, Hamm C, Braun-Dullaeus R. Role of the phosphatase PTEN in early vascular remodeling. PLoS One 8(3):e55445, 2013.  

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Sheikh AQ, Kuesel C, Taghian T, Hurley JR, Huang W, Wang Y, Hinton RB, Narmoneva DA. Angiogenic microenvironment augments impaired endothelial responses under diabetic conditions. Am J Physiol Cell Physiol 306(8):C768-78, 2014.  

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Sun L, Qu L, Zhu R, Li H, Xue Y, Liu X, Fan J, Fan H. Effects of mechanical stretch on cell proliferation and matrix formation of mesenchymal stem cell and anterior cruciate ligament fibroblast. Stem Cells Int. 2016:9842075, 2016.

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Tamiello C, Bouten CV, Baaijens FP. Competition between cap and basal actin fiber orientation in cells subjected to contact guidance and cyclic strain. Sci Rep 5:8752, 2015.

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Tamiello C, Halder M, Kamps MA, Baaijens FP, Broers JL, Bouten CV. Cellular strain avoidance is mediated by a functional actin cap - observations in an Lmna-deficient cell model. J Cell Sci 130(4):779-790, 2017.  

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Thodeti CK, Matthews B, Ravi A, Mammoto A, Ghosh K, Bracha AL, Ingber DE. TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling. Circ Res 104(9):1123-1130, 2009.

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Thompson CL, Chapple JP, Knight MM. Primary cilia disassembly down-regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes. Osteoarthritis Cartilage 22(3):490-8, 2014.  

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Tondon A, Haase C, Kaunas R. Mechanical stretch assays in cell culture systems. In: Handbook of Imaging in Biological Mechanics, ed. Neu CP, Genin GM. CRC Press: Boca Raton, 2015.

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Wescott DC, Pinkerton MN, Gaffey BJ, Beggs KT, Milne TJ, Meikle MC. Osteogenic gene expression by human periodontal ligament cells under cyclic tension. J Dent Res 86(12):1212-1216, 2007.

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Wilson CJ, Kasper G, Schütz MA, Duda GN. Cyclic strain disrupts endothelial network formation on Matrigel. Microvasc Res 78(3):358-63, 2009

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