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Flexcell® Cell Stretching Bioreactors & Cultureware
We provide solutions for life science research. American owned and operated.
See The Flexcell® Difference
Flexcell® has spent over three decades focusing on creating products utilizing vacuum pressure technology to stimulate cells in culture, which is relevant to the detection and response of cells to physical forces through signaling pathways, crucial for advancing therapies and drugs.
Tension Systems
Our FX-6000T™ Tension System is a computer-regulated bioreactor that uses positive and negative air pressure to apply cyclic or static mechanical strain to cells cultured on flexible-bottomed culture plates. The FX-6000T™ Tension System allows researchers to simulate in vivo tissue strains and frequencies in vitro that mimic in vivo conditions in cells from muscle, lung, heart, vascular vessels, skin, tendon, ligament, cartilage, and bone.
Compression Systems
Flexcell’s® Compression System regulates positive air pressure to compress tissue samples or 3D cell cultures in vitro. The FX-5000C™ Compression System compresses samples between a piston and stationary platen using our BioPress™ culture plates. It can load up to 14 lbs. of applied force. Using the FX-5000C™ Compression System, researchers can observe biochemical changes and cell signaling in vitro that mimics in vivo conditions.
Fluid Shear Systems
Flexcell’s® Compression System regulates positive air pressure to compress tissue samples or 3D cell cultures in vitro. The FX-5000C™ Compression System compresses samples between a piston and stationary platen using our BioPress™ culture plates. It can load up to 14 lbs. of applied force. Using the FX-5000C™ Compression System, researchers can observe biochemical changes and cell signaling in vitro that mimics in vivo conditions.
System Applications
In vitro models, tissue engineering, and drug discovery applications play a crucial role in advancing scientific knowledge and improving medical interventions.
In Vitro Modeling
Repeatable, Reliable, and Reproducible Solutions for Life Science Research
Flexcell® Bioreactor Systems enhance in vitro modeling in various fields such as osteoarthritis, osteogenesis, cardiac tissue engineering, lung injury, traumatic brain injury, tendinopathy, cartilage repair, muscle hypertrophy, pulmonary fibrosis, cardiovascular disease, bioengineered tissues, cancer metastasis, glaucoma, endothelial dysfunction, and wound healing. Empirically observed changes in gene/protein expression, mechanosensitive receptors, cell signaling pathways, ion channels (Piezo1, 2, Ca+), and cell behavior can be achieved in a mechanically active environment.
Tissue Engineering
Functional, Controllable, Tunable Components to Advance Tissue Engineering
Our Tissue Train® 3D Cell Culture System enables mechanical loading of 3D cell-seeded hydrogel scaffolds. This allows for the development of bioengineered constructs, advancing our understanding of disease mechanisms and tissue repair. With flexible membrane disposables that mimic native tissue stiffnesses, our culture plates offer groundbreaking solutions for tissue engineering. Soft substrates have proven effective for sensitive cell lines prolonging phenotype senescence, improving bioprocessing and regenerative medicine applications.
Drug Discovery
Streamlined, Sustainable and Cost-Effective Dynamic Drug Discovery
Flexcell® Bioreactor Systems create optimal environments that closely mimic the human body, providing valuable insights into cellular metabolism and disease pathways. For example, the presence of mechanical forces in tumors has significant implications for physiological response and the effectiveness of therapeutic agents, notably to decrease cell proliferation, cell survival and the efficacy of chemotherapy. Data suggests that considering mechanical forces in the development of screening assays could improve antitumor drug discovery efforts.
Client Testimonials
Dr. Klymenko, Department of Biological Sciences, University of Notre Dame, USA
Client Testimonials
Dr. Riehl, Department of Mechanical and Materials Engineering, College of Engineering, University of Nebraska-Lincoln, USA
Client Testimonials
Dr. Wang, Institute of Mechanobiology & Medical Engineering, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, P.R. China
Publications
At Flexcell® International Corporation, we understand that our commitment to the highest quality products and customer service depend on our ability to take part in research and development continuously. We invite you to read more about our ongoing research and development on cell stretching bioreactors in tissue engineering, cellular mechanics, gene and protein expression, cytomechanics, drug discovery, orthopedics, cardiovascular, and pulmonary research.
Get In Touch
At Flexcell® International Corporation, we understand that our commitment to the highest quality products and customer service are core to our business. Reach out to us today to see how we can apply those principals to your business.
View Our Products
View our full range of tissue engineering accessories and disposables to complement our cell stretching bioreactors and aid in the construction of 3D cell-seeded tissue constructs with different shape sizes.