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Mechanical loading is a fundamental factor in regulating cellular behavior, particularly in the context of stem cell proliferation, differentiation, and function. In native tissues, cells are continuously subjected to mechanical cues such as tension, compression, and shear forces, which influence their development and response to physiological stimuli.

In the realm of scientific progress, milestones mark not just accomplishments but also the evolution of ideas that redefine entire fields. As Flexcell® International Corporation commemorates its 36 th year in business, we reflect on a journey that began with a visionary idea and transformed into a pioneering force in the now, recognized fields of Mechanobiology and Tissue Engineering.

After many long months of hard work, a sincere congratulations goes to Team Platron for the successful design, development and testing of our groundbreaking automation system for disposables chemistry treatment. This achievement marks a significant milestone for Flexcell® International Corporation and we proudly dedicate the Platron system to Mr. Robert H. Tatro for his invaluable years of service.

Flexcell® International Corp. is pleased to announce the appointment of Andrea Picon as Chief Operating Officer, effective November 18th, 2021. Andrea joined Flexcell® International Corp. in 2017 as Director of New Business Development. She has been responsible for identifying target channels, product portfolio analysis, e-business strategy, developing international distributor partners and improving internal business operating processes.

Congratulations to Dr. David Julius and Dr. Ardem Patapoutian for winning the Nobel Prize in Physiology or Medicine with their groundbreaking research that solved a long-standing mystery of how the body senses touch and other mechanical stimuli! The Nobel Prize committee cited the discoveries by Patapoutian and his colleagues of two ion channels, PIEZO1 and PIEZO2, that are necessary for the cells to respond to mechanical stimuli. Patapoutian says he had originally set out to investigate a fundamental question, how pressure and touch are perceived. But simple questions led to very complex discoveries, which continue today.

In this study, human ADSCs (hADSCs) were applied cyclic stretch stimulation under an in vitro stretching model for designated duration. We found that mechanical stretch significantly promoted the proliferation, adhesion and migration of hADSCs, suppressing cellular apoptosis and increasing the production of pro‐healing cytokines.

The Biotechnology Department at Alamance Community College (ACC) shows no signs of slowing down its historic push to provide students with the latest cutting-edge training in new technologies that have long paved the way for career opportunities in the biomanufacturing industry.

Burlington’s Flexcell® has manufactured scientific products for testing cell-level biochemical reactions since 1987. Flexcell® products have medical applications across fields like orthopedics, cardiovascular medicine, pulmonary health, and tissue engineering research.

Mesenchymal stem cells (MSCs) and fibroblasts are two major seed cells for ligament tissue engineering. To understand the effects of mechanical stimulation on these cells and to develop effective approaches for cell therapy, it is necessary to investigate the biological effects of various mechanical loading conditions on cells.

Abstract Human pluripotent stem cell-derived cardiomyocytes (hPSC-CM) represent a potential unlimited cell supply for cardiac tissue engineering and possibly regenerative medicine applications.