Publications Searchable Database

Flexcell® products are cited in over 6,700 science publications world-wide.

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COVID/SARS
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In Vitro Lung Model
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Mechanical Force-induced Osteogenesis
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13 Fibrotic regulators Ccn1 and Ccn2 respond to mechanical loading of tendon cells
Andersson G, Backman L. 13 Fibrotic regulators Ccn1 and Ccn2 respond to mechanical loading of tendon cells. Br J Sports Med 48:A8-A9, 2014.
Year: 
2014
Organ System: 
Tissue Type: 
Tendon
Cell Type: 
Flexcell System Used: 
17-estradiol inhibits cyclic strain-induced endothelin-1 gene expression within vascular endothelial cells
Juan SH, Chen JJ, Chen CH, Lin H, Cheng CF, Liu JC, Hsieh MH, Chen YL, Chao HH, Chen TH, Chan P, Cheng TH. 17-estradiol inhibits cyclic strain-induced endothelin-1 gene expression within vascular endothelial cells. Am J Physiol Heart Circ Physiol 287(3):H1254-H1261, 2004.
Year: 
2004
Organ System: 
Tissue Type: 
Cardiovasculure
Cell Type: 
Endothelial
Flexcell System Used: 
17beta-Estradiol modulates mechanical strain-induced MAPK activation in mesangial cells
Krepinsky J, Ingram AJ, James L, Ly H, Thai K, Cattran DC, Miller JA, Scholey JW. 17beta-Estradiol modulates mechanical strain-induced MAPK activation in mesangial cells. J Biol Chem 277(11):9387-9394, 2002.
Year: 
2002
Organ System: 
Tissue Type: 
Kidney
Cell Type: 
Mesangial
Flexcell System Used: 
17beta-estradiol inhibition of NADPH oxidase expression in human endothelial cells
Wagner AH, Schroeter MR, Hecker M. 17beta-estradiol inhibition of NADPH oxidase expression in human endothelial cells. FASEB J 15(12):2121-2130, 2001.
Year: 
2001
Organ System: 
Tissue Type: 
Cell Type: 
Flexcell System Used: 
1P-0151 Cyclic stretch induced reactive oxygen species (ROS) enhances apoptosis in porcine retinal pericytes (PRPC) through JNK/SAPK activation [abstract]
Suzuma I, Suzuma K, Takagi H, Kaneto H, Aiello L, Honda Y. 1P-0151 Cyclic stretch induced reactive oxygen species (ROS) enhances apoptosis in porcine retinal pericytes (PRPC) through JNK/SAPK activation [abstract]. Atherosclerosis Supplements 4(2):53, 2003.
Year: 
2003
Organ System: 
Tissue Type: 
Eye
Cell Type: 
Flexcell System Used: 
3D in vitro morphogenesis of human intestinal epithelium in a gut-on-a-chip or a hybrid chip with a cell culture insert
Shin, W., Kim, H.J. 3D in vitro morphogenesis of human intestinal epithelium in a gut-on-a-chip or a hybrid chip with a cell culture insert. Nat Protocol 17, 910–939, 2022.
Year: 
2022
Organ System: 
Tissue Type: 
Epithelial Cells
Cell Type: 
Caco-2 Intestinal
Flexcell System Used: 
A cell-culture system for long-term maintenance of elevated hydrostatic pressure with the option of additional tension
Hasel C, Durr S, Bruderlein S, Melzner I, Moller P. A cell-culture system for long-term maintenance of elevated hydrostatic pressure with the option of additional tension. J Biomechanics 35(5):579-584, 2002.
Year: 
2002
Organ System: 
Tissue Type: 
Cell Type: 
Flexcell System Used: 
A central role for the nuclear factor-B pathway in anti-inflammatory and proinflammatory actions of mechanical strain
Agarwal S, Long P, Seyedain A, Piesco N, Shree A, Gassner R. A central role for the nuclear factor-B pathway in anti-inflammatory and proinflammatory actions of mechanical strain. FASEB J 17(8):899-901, 2003.
Year: 
2003
Organ System: 
Tissue Type: 
Ligament
Cell Type: 
Periodontal
Flexcell System Used: 
A disintegrin and metalloprotease-17 regulates pressure overload-induced myocardial hypertrophy and dysfunction through proteolytic processing of integrin β1
Fan D, Takawale A, Shen M, Samokhvalov V, Basu R, Patel V, Wang X, Fernandez-Patron C, Seubert JM, Oudit GY, Kassiri Z. A disintegrin and metalloprotease-17 regulates pressure overload-induced myocardial hypertrophy and dysfunction through proteolytic processing of integrin β1. Hypertension 68(4):937-48, 2016.
Year: 
2016
Organ System: 
Tissue Type: 
Cardiovasculure
Cell Type: 
Cardiomyocytes
Flexcell System Used: 
A dystroglycan/plectin scaffold mediates mechanical pathway bifurcation in lung epithelial cells
Takawira D, Budinger GR, Hopkinson SB, Jones JC. A dystroglycan/plectin scaffold mediates mechanical pathway bifurcation in lung epithelial cells. J Biol Chem 286(8):6301-6310, 2011.
Year: 
2011
Organ System: 
Tissue Type: 
Pulmonary
Cell Type: 
Epithelial
Flexcell System Used: 
A fluorescence energy transfer-based mechanical stress sensor for specific proteins in situ
Meng F, Suchyna TM, Sachs F. A fluorescence energy transfer-based mechanical stress sensor for specific proteins in situ. FEBS J 275(12):3072-3087, 2008.
Year: 
2008
Organ System: 
Tissue Type: 
Cell Type: 
Flexcell System Used: 
A molecular mechanism of integrin regulation from bone cells stimulated by orthodontic forces
Calvalho RS, Bumann A, Schwarzer C, Scott E, Yen EH. A molecular mechanism of integrin regulation from bone cells stimulated by orthodontic forces. Eur J Orthod 18(3):227-235, 1996.
Year: 
1996
Organ System: 
Tissue Type: 
Bone
Cell Type: 
Flexcell System Used: 
A new experimental system for the extended application of cyclic hydrostatic pressure to cell culture
Maul TM, Hamilton DW, Nieponice A, Soletti L, Vorp DA. A new experimental system for the extended application of cyclic hydrostatic pressure to cell culture. J Biomech Eng 129(1):110-6, 2007.
Year: 
2007
Organ System: 
Tissue Type: 
Cell Type: 
Flexcell System Used: 
A new vacuum-operated stress-providing instrument that applies static or variable duration cyclic tension or compression to cells in vitro
Banes AJ, Gilbert J, Taylor D, Monbureau O. A new vacuum-operated stress-providing instrument that applies static or variable duration cyclic tension or compression to cells in vitro. J Cell Sci 75:35-42, 1985.
Year: 
1985
Organ System: 
Tissue Type: 
Tendon
Cell Type: 
Flexcell System Used: 
A novel in vitro model of lymphatic metastasis from colorectal cancer
Yoo PS, Mulkeen AL, Dardik A, Cha CH. A novel in vitro model of lymphatic metastasis from colorectal cancer. J Surg Res 143(1):94-98, 2007.
Year: 
2007
Organ System: 
Tissue Type: 
Cell Type: 
Flexcell System Used: 
Fluid Shear Systems
A novel ligand-independent function of the estrogen receptor is essential for osteocyte and osteoblast mechanotransduction
Aguirre JI, Plotkin LI, Gortazar AR, Millan MM, O'Brien CA, Manolagas SC, Bellido T. A novel ligand-independent function of the estrogen receptor is essential for osteocyte and osteoblast mechanotransduction. J Biol Chem 282(35):25501–25508, 2007.
Year: 
2007
Organ System: 
Tissue Type: 
Bone
Cell Type: 
Flexcell System Used: 
A novel method for assessing adherent single-cell stiffness in tension: design and testing of a substrate-based live cell functional imaging device
Bartalena G, Grieder R, Sharma RI, Zambelli T, Muff R, Snedeker JG. A novel method for assessing adherent single-cell stiffness in tension: design and testing of a substrate-based live cell functional imaging device. Biomed Microdevices 13(2):291-301, 2011.
Year: 
2011
Organ System: 
Tissue Type: 
Cell Type: 
Flexcell System Used: 
Tension Systems
A novel role for primary cilia in airway remodeling
Trempus CS, Song W, Lazrak A, Yu Z, Creighton JR, Young BM, Heise RL, Yu YR, Ingram JL, Tighe RM, Matalon S, Garantziotis S. A novel role for primary cilia in airway remodeling. Am J Physiol Lung Cell Mol Physiol 313(2):L328-L338, 2017.
Year: 
2017
Organ System: 
Tissue Type: 
Lung
Cell Type: 
Smooth Muscle
Flexcell System Used: 
A phosphoinositide-binding cluster in cavin1 acts as a molecular sensor for cavin1 degradation
Tillu VA, Kovtun O, McMahon KA, Collins BM, Parton RG. A phosphoinositide-binding cluster in cavin1 acts as a molecular sensor for cavin1 degradation. Mol Biol Cell 26(20):3561-9, 2015.
Year: 
2015
Organ System: 
Tissue Type: 
Other Cell Types
Cell Type: 
Flexcell System Used: 
A relationship between vascular endothelial growth factor, angiogenesis, and cardiac repair after muscle stem cell transplantation into ischemic hearts
Payne TR, Oshima H, Okada M, Momoi N, Tobita K, Keller BB, Peng H, Huard J. A relationship between vascular endothelial growth factor, angiogenesis, and cardiac repair after muscle stem cell transplantation into ischemic hearts. J Am Coll Cardiol 50(17):1677-1684, 2007.
Year: 
2007
Organ System: 
Tissue Type: 
Stem & Progenitor Cells
Cell Type: 
Flexcell System Used: 
A role for caveolin-1 in mechanotransduction of fetal type II epithelial cells
Wang Y, Maciejewski BS, Drouillard D, Santos M, Hokenson MA, Hawwa RL, Huang Z, Sanchez-Esteban J. A role for caveolin-1 in mechanotransduction of fetal type II epithelial cells. Am J Physiol Lung Cell Mol Physiol 298(6):L775-L783, 2010.
Year: 
2010
Organ System: 
Tissue Type: 
Pulmonary
Cell Type: 
Epithelial
Flexcell System Used: 
A role for focal adhesion kinase in cardiac mitochondrial biogenesis induced by mechanical stress
Tornatore TF, Dalla Costa AP, Clemente CF, Judice C, Rocco SA, Calegari VC, Cardoso L, Cardoso AC, Gonçalves A Jr, Franchini KG. A role for focal adhesion kinase in cardiac mitochondrial biogenesis induced by mechanical stress. Am J Physiol Heart Circ Physiol 300(3):H902-H912, 2011.
Year: 
2011
Organ System: 
Tissue Type: 
Cardiovasculure
Cell Type: 
Cardiomyocytes
Flexcell System Used: 
A simple device to apply equibiaxial strain to cells cultured on flexible membranes
Rana OR, Zobel C, Saygili E, Brixius K, Gramley F, Schimpf T, Mischke K, Frechen D, Knackstedt C, Schwinger RH, Schauerte P, Saygili E. A simple device to apply equibiaxial strain to cells cultured on flexible membranes. Am J Physiol Heart Circ Physiol 294(1):H532-540, 2008.
Year: 
2008
Organ System: 
Tissue Type: 
Cell Type: 
Flexcell System Used: 
A three-dimensional gel bioreactor for assessment of cardiomyocyte induction in skeletal muscle-derived stem cells
Clause KC, Tinney JP, Liu LJ, Gharaibeh B, Huard J, Kirk JA, Shroff SG, Fujimoto KL, Wagner WR, Ralphe JC, Keller BB, Tobita K. A three-dimensional gel bioreactor for assessment of cardiomyocyte induction in skeletal muscle-derived stem cells. Tissue Eng Part C Methods 16(3):375-385, 2010.
Year: 
2010
Organ System: 
Tissue Type: 
Cell Type: 
Flexcell System Used: 
ACE inhibitor and AT1 antagonist blockade of deformation-induced gene expression in the rabbit jugular vein through B2 receptor activation
Lauth M, Cattaruzza M, Hecker M. ACE inhibitor and AT1 antagonist blockade of deformation-induced gene expression in the rabbit jugular vein through B2 receptor activation. Arterioscler Thromb Vasc Biol 21(1):61-6, 2001.
Year: 
2001
Organ System: 
Tissue Type: 
Cardiovasculure
Cell Type: 
Endothelial
Flexcell System Used: 
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