BioFlex® Culture Plates

Flexible-bottomed culture plates that work with the Flexcell® Tension System to provide a mechanical load regimen to cells in monolayer (2D).

• 6-well culture plate with total growth surface area of 57.75 cm2 (or 9.62 cm2/well)
• Rubber membranes are optically clear for direct viewing of cells with an inverted or upright microscope
• Covalently bonded matrix surfaces: Amino, Collagen (Type I or IV), and Laminin (YIGSR) and Untreated
• Available individually or in case quantity of 40 plates

Applications of BioFlex® Culture Plates

• Mechanical Load - use with Flexcell® Tension System to research the effects of equibiaxial tensile strain on cells in vitro
• Softer Substrate - provides a softer substrate for cell growth (when compared to standard plastic culture dishes) which better mimics in situ conditions for some cell types like trabecular meshwork cells (see Aga et al. Invest Ophthalmol Vis Sci 55(9):5497-509, 2014)
• Lung Injury Models - Used to understand the impact of ARDS, COPD, COVID-19 related pulmonary injuries by simulating "cytokine storm", hyper-tension and hyperventilation to cells in vitro (See Huang et al., Am J Respir Crit Care Med., 195(5):639-65, 2017; Ke et al.,Mol iol Cell.30(8): 959–974

• Traumatic Brain Injury - can be used in studies looking at traumatic injury in astrocytes and neurons, where the injury is produced with a Cell Injury Controller that controls a burst of gas which deforms the BioFlex® membrane creating large biaxial strains (see Ellis et al. J Neurotrauma 12 325–339, 1995; Ahmed et al. J Neurochem 74(5):1951-1960, 2000; Augustine et al. Neuroscience 274:1-10, 2014)