Publications Searchable Database

Flexcell® products are cited in over 6,700 science publications world-wide.

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COVID/SARS
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In Vitro Lung Model
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Injectable Hydrogel Study
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Ion Channels
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Mechanical Force-induced Osteogenesis
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ACE inhibitor and AT1 antagonist blockade of deformation-induced gene expression in the rabbit jugular vein through B2 receptor activation
Lauth M, Cattaruzza M, Hecker M. ACE inhibitor and AT1 antagonist blockade of deformation-induced gene expression in the rabbit jugular vein through B2 receptor activation. Arterioscler Thromb Vasc Biol 21(1):61-6, 2001.
Year: 
2001
Organ System: 
Tissue Type: 
Cardiovasculure
Cell Type: 
Endothelial
Flexcell System Used: 
AP-1 mediates stretch-induced expression of HB-EGF in bladder smooth muscle cells
Park JM, Adam RM, Peters CA, Guthrie PD, Sun Z, Klagsbrun M, Freeman MR. AP-1 mediates stretch-induced expression of HB-EGF in bladder smooth muscle cells. Am J Physiol Cell Physiol 277:C294-C301, 1999.
Year: 
1999
Organ System: 
Tissue Type: 
Bladder
Cell Type: 
Smooth Muscle
Flexcell System Used: 
ATP modulates load-inducible IL-1, COX 2, and MMP-3 gene expression in human tendon cells
Tsuzaki M, Bynum D, Almekinders L, Yang X, Faber J, Banes AJ. ATP modulates load-inducible IL-1, COX 2, and MMP-3 gene expression in human tendon cells. J Cell Biochem 89(3):556-562, 2003.
Year: 
2003
Organ System: 
Tissue Type: 
Tendon
Cell Type: 
Flexcell System Used: 
ATP reduces gel compaction in osteoblast-populated collagen gels
Qi J, Chi L, Faber J, Koller B, Banes AJ. ATP reduces gel compaction in osteoblast-populated collagen gels. J Appl Physiol 102(3):1152-60, 2007.
Year: 
2007
Organ System: 
Tissue Type: 
Bone
Cell Type: 
Flexcell System Used: 
ATP release by mechanically loaded porcine chondrons in pellet culture
Graff RD, Lazarowski ER, Banes AJ, Lee GM. ATP release by mechanically loaded porcine chondrons in pellet culture. Arthritis Rheum 43(7):1571-1579, 2000.
Year: 
2000
Organ System: 
Tissue Type: 
Cell Type: 
Flexcell System Used: 
Compression System
Ablation of cardiac myosin-binding protein-C accelerates contractile kinetics in engineered cardiac tissue
de Lange WJ, Grimes AC, Hegge LF, Ralphe JC. Ablation of cardiac myosin-binding protein-C accelerates contractile kinetics in engineered cardiac tissue. J Gen Physiol 141(1):73-84, 2013.
Year: 
2013
Organ System: 
Tissue Type: 
Cell Type: 
Flexcell System Used: 
Actin isoform and 1B-adrenoceptor gene expression in aortic and coronary smooth muscle is influenced by cyclical stretch
Lundberg MS, Sadhu DN, Grumman VE, Chilian WM, Ramos KS. Actin isoform and 1B-adrenoceptor gene expression in aortic and coronary smooth muscle is influenced by cyclical stretch. In Vitro Cell Dev Biol Anim 31(8):595-600, 1995.
Year: 
1995
Organ System: 
Tissue Type: 
Cardiovasculure
Cell Type: 
Smooth Muscle
Flexcell System Used: 
Actin stress fibres and cell-cell adhesion molecules in tendons: organisation in vivo and response to mechanical loading of tendon cells in vitro
Ralphs JR, Waggett AD, Benjamin M. Actin stress fibres and cell-cell adhesion molecules in tendons: organisation in vivo and response to mechanical loading of tendon cells in vitro. Matrix Biology 21(1):67-74, 2002.
Year: 
2002
Organ System: 
Tissue Type: 
Tendon
Cell Type: 
Flexcell System Used: 
Activation of NLRP3 inflammasome in alveolar macrophages contributes to mechanical stretch-induced lung inflammation and injury
Wu J, Yan Z, Schwartz DE, Yu J, Malik AB, Hu G. Activation of NLRP3 inflammasome in alveolar macrophages contributes to mechanical stretch-induced lung inflammation and injury. J Immunol 190(7):3590-9, 2013.
Year: 
2013
Organ System: 
Tissue Type: 
Lung
Cell Type: 
Alveolar
Flexcell System Used: 
Activation of PDGF receptor  in vascular smooth muscle cells by mechanical stress
Hu Y, Bock G, Wick G, Xu Q. Activation of PDGF receptor  in vascular smooth muscle cells by mechanical stress. FASEB J 12(12):1135-1142, 1998.
Year: 
1998
Organ System: 
Tissue Type: 
Cardiovasculure
Cell Type: 
Smooth Muscle
Flexcell System Used: 
Activation of S6 kinase by repeated cycles of stretching and relaxation in rat glomerular mesangial cells
Homma T, Akai Y, Burns KD, Harris RC. Activation of S6 kinase by repeated cycles of stretching and relaxation in rat glomerular mesangial cells. Evidence for involvement of protein kinase C. J Biol Chem 267(32):23129-23135, 1992.
Year: 
1992
Organ System: 
Tissue Type: 
Kidney
Cell Type: 
Mesangial
Flexcell System Used: 
Activation of a local tissue angiotensin system in podocytes by mechanical strain
Durvasula RV, Petermann AT, Hiromura K, Blonski M, Pippin J, Mundel P, Pichler R, Griffin S, Couser WG, Shankland SJ. Activation of a local tissue angiotensin system in podocytes by mechanical strain. Kidney International 65(1):30-39, 2004.
Year: 
2004
Organ System: 
Tissue Type: 
Kidney
Cell Type: 
Flexcell System Used: 
Activation of a signaling cascade by cytoskeleton stretch
Tamada M, Sheetz MP, Sawada Y. Activation of a signaling cascade by cytoskeleton stretch. Dev Cell 7:709-718, 2004.
Year: 
2004
Organ System: 
Tissue Type: 
Cell Type: 
Flexcell System Used: 
Activation of c-Src tyrosine kinase mediated the degradation of occludin in ventilator-induced lung injury
Zhao T, Liu M, Gu C, Wang X, Wang Y. Activation of c-Src tyrosine kinase mediated the degradation of occludin in ventilator-induced lung injury. Respir Res 15:158, 2014.
Year: 
2014
Organ System: 
Tissue Type: 
Pulmonary
Cell Type: 
Epithelial
Flexcell System Used: 
Activation of cell adhesion kinase beta by mechanical stretch in vascular smooth muscle cells
Iwasaki H, Yoshimoto T, Sugiyama T, Hirata Y. Activation of cell adhesion kinase beta by mechanical stretch in vascular smooth muscle cells. Endocrinology 144(6):2304-2310, 2003.
Year: 
2003
Organ System: 
Tissue Type: 
Cardiovasculure
Cell Type: 
Smooth Muscle
Flexcell System Used: 
Activation of diacylglycerol in cultured endothelial cells exposed to cyclic strain
Evans L, Frenkel L, Brophy CM, Rosales O, Sudhaker CB, Li G, Du W, Sumpio BE. Activation of diacylglycerol in cultured endothelial cells exposed to cyclic strain. Am J Physiol 272(2 Pt 1):C650-C656, 1997.
Year: 
1997
Organ System: 
Tissue Type: 
Cardiovasculure
Cell Type: 
Endothelial
Flexcell System Used: 
Activation of endothelial nitric oxide (eNOS) occurs through different membrane domains in endothelial cells
Tran J, Magenau A, Rodriguez M, Rentero C, Royo T, Enrich C, Thomas SR, Grewal T, Gaus K. Activation of endothelial nitric oxide (eNOS) occurs through different membrane domains in endothelial cells. PLoS One 11(3):e0151556, 2016.
Year: 
2016
Organ System: 
Tissue Type: 
Cell Type: 
Flexcell System Used: 
Fluid Shear Systems
Activation of extracellular signal-regulated kinase by stretchinduced injury in astrocytes involves extracellular ATP and P2 purinergic receptors
Neary JT, Kang Y, Willoughby KA, Ellis EF. Activation of extracellular signal-regulated kinase by stretchinduced injury in astrocytes involves extracellular ATP and P2 purinergic receptors. J Neurosci 23(6):23482356, 2003.
Year: 
2003
Organ System: 
Tissue Type: 
Cell Type: 
Flexcell System Used: 
Activation of extracellular signal-regulated kinase is involved in mechanical strain inhibition of RANKL expression in bone stromal cells
Rubin J, Murphy TC, Fan X, Goldschmidt M, Taylor WR. Activation of extracellular signal-regulated kinase is involved in mechanical strain inhibition of RANKL expression in bone stromal cells. J Bone Miner Res 17(8):1452-1460, 2002.
Year: 
2002
Organ System: 
Tissue Type: 
Stem & Progenitor Cells
Cell Type: 
Flexcell System Used: 
Activation of fibroblast procollagen alpha1(I) transcription by mechanical strain is transforming growth factor-beta-dependent and involves increased binding of CCAAT-binding factor (CBF/NF-Y) at the proximal promoter
Lindahl GE, Chambers RC, Papakrivopoulou J, Dawson SJ, Jacobsen MC, Bishop JE, Laurent GJ. Activation of fibroblast procollagen alpha1(I) transcription by mechanical strain is transforming growth factor-beta-dependent and involves increased binding of CCAAT-binding factor (CBF/NF-Y) at the proximal promoter. J Biol Chem 277(8):6153-6161, 2002.
Year: 
2002
Organ System: 
Tissue Type: 
Cardiovasculure
Cell Type: 
Cardiomyocytes
Flexcell System Used: 
Activation of heat shock transcription factor 1 in atherosclerosis
Metzler B, Abia R, Ahmad M, Wernig F, Pachinger O, Hu Y, Xu Q. Activation of heat shock transcription factor 1 in atherosclerosis. Am J Pathol 162(5):1669-1676, 2003.
Year: 
2003
Organ System: 
Tissue Type: 
Cardiovasculure
Cell Type: 
Smooth Muscle
Flexcell System Used: 
Activation of human macrophages by mechanical ventilation in vitro
Pugin J, Dunn I, Jolliet P, Tassaux D, Magnenat JL, Nicod LP, Chevrolet JC. Activation of human macrophages by mechanical ventilation in vitro. Am J Physiol Lung Cell Mol Physiol 275:L1040-L1050, 1998.
Year: 
1998
Organ System: 
Tissue Type: 
Cell Type: 
Flexcell System Used: 
Activation of mesangial cell signaling cascades in response to mechanical strain
Ingram AJ, Ly H, Thai K, Kang M, Scholey JW. Activation of mesangial cell signaling cascades in response to mechanical strain. Kidney International 55(2):476-485, 1999.
Year: 
1999
Organ System: 
Tissue Type: 
Kidney
Cell Type: 
Mesangial
Flexcell System Used: 
Activation of mitogenic and antimitogenic pathways in cyclically stretched arterial smooth muscle
Standley PR, Stanley MA, Senechal P. Activation of mitogenic and antimitogenic pathways in cyclically stretched arterial smooth muscle. Am J Physiol Endocrinol Metab 281(6):E1165-E1171, 2001.
Year: 
2001
Organ System: 
Tissue Type: 
Cardiovasculure
Cell Type: 
Smooth Muscle
Flexcell System Used: 
Activation of stress-activated protein kinases (SAPK) in tendon cells following cyclic strain: the effects of strain frequency, strain magnitude, and cytosolic calcium
Arnoczky SP, Tian T, Lavagnino M, Gardner K, Schuler P, Morse P. Activation of stress-activated protein kinases (SAPK) in tendon cells following cyclic strain: the effects of strain frequency, strain magnitude, and cytosolic calcium. Journal of Orthopaedic Research 20(5):947-952, 2002.
Year: 
2002
Organ System: 
Tissue Type: 
Tendon
Cell Type: 
Flexcell System Used: 
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