Tension Cell Stretching Bioreactor System

About Our Tension Systems

Flexcell® Tension Systems are patented, computer-regulated bioreactors that apply cyclic or static strain to cells cultured in vitro. We designed Flexcell® Tension Systems to help investigators analyze biochemical changes in response to tensile load on a variety of cell culture applications, including muscle, lung, heart, vascular vessels, skin, tendon, ligament, cartilage, and bone. Our Tension Systems work with UniFlex® (Uniaxial strain) and/or BioFlex® (Equibiaxial strain) culture plates.

How Our Tension Bioreactors Work

Our cell stretching bioreactor systems are great for the stimulation of cells in cell culture using mechanical strain. Using our pneumatic stretching protocol system instead of a motor-driven or electrical system allows you to avoid any confounding vibrational strain, or electronic (E), or magnetic fields (B).
Application of equibiaxial strain with Flexcell® Tension Systems using Bioflex® culture plates

Our Different Tension Systems

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What our customers say

“Cells were seeded on flexible silicone-bottom plates (Flexcell® Tension System) at a density of 3 × 105 cells per well. Pathologically elevated cyclic stretch increased the secretion of miR-27a, which was transferred from VSMCs to ECs via the VSMC-MPs, subsequently targeted GRK6, and induced EC proliferation. Locally decreasing miR-27a could be a novel therapeutic approach to attenuate the abnormal EC proliferation in hypertension.”

Dr. Wang, Institute of Mechanobiology & Medical Engineering, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, P.R. China

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“A Flexcell® Compression Plus system was used to enable longer-term compression of multicellular aggregates (MCAs) in custom-designed hydrogel carriers. Results show changes in the expression of genes related to epithelial-mesenchymal transition as well as altered dispersal of compressed MCAs on collagen gels.”

Dr. Klymenko, Department of Biological Sciences, University of Notre Dame, USA

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“The study of fluid shear as a driving force for cell migration, i.e., "flowtaxis", and investigation of molecular mechanosensors governing such behavior (e.g., ROCK as tested in this study) may provide new and improved insights into the fundamental understanding of cell migration-based homeostasis. The flow regimens could be controlled by the peristaltic pump and the Osci-Flow device, which were governed by StreamSoft v. 4.1 software provided by Flexcell® International Corp.”

Dr. Riehl, Department of Mechanical and Materials Engineering, College of Engineering, University of Nebraska-Lincoln, USA

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Our Commitment to Ongoing Research

At Flexcell® International Corporation, we understand that our commitment to the highest quality products and customer service depend on our ability to take part in research and development continuously.We invite you to read more about our ongoing research and development on cell stretching bioreactors in tissue engineering, cellular mechanics, gene and protein expression, cytomechanics, drug discovery, orthopaedics, cardiovascular, and pulmonary research.

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