Whether you want to stretch cells in Monolayer (2D) or create Tissue Constructs in (3D) cell culture, we have the disposable solution to meet your needs!
Monolayer (2D) Culture Plates:
BioFlex®, HT BioFlex®, UniFlex®, BioPress™, CellSoft® Soft Substrates
Tissue Constructs and (3D) Culture Plates:
Tissue Train® Culture Plates are available in 3 shapes (Circular, Linear and Trapezoidal) with either Cyrex mesh or foam anchors to attach 3D constructs for stretch
Culture Plate by Strain Application:
Equibiaxial load: BioFlex®, HT BioFlex®, CellSoft®, Tissue Train® Circular
Uniaxial load: UniFlex®, Tissue Train® Linear, Tissue Train® Trapezoidal
The rubber membranes in our culture plates are optically clear for direct viewing of cells.
Our specially designed flexible bottomed 6-well and 24-well BioFlex® culture plates are offered in a range of protein coatings: Amino, Collagen (Type I and IV), Elastin, Pronectin (RGD) and Laminin (YIGSR) that save the researcher time and money. Our culture plates also come untreated for use with a lab's own custom ECM coating protocol.
“Cells were seeded on flexible silicone-bottom plates (Flexcell® Tension System) at a density of 3 × 105 cells per well. Pathologically elevated cyclic stretch increased the secretion of miR-27a, which was transferred from VSMCs to ECs via the VSMC-MPs, subsequently targeted GRK6, and induced EC proliferation. Locally decreasing miR-27a could be a novel therapeutic approach to attenuate the abnormal EC proliferation in hypertension.”
“A Flexcell® Compression Plus system was used to enable longer-term compression of multicellular aggregates (MCAs) in custom-designed hydrogel carriers. Results show changes in the expression of genes related to epithelial-mesenchymal transition as well as altered dispersal of compressed MCAs on collagen gels.”
“The study of fluid shear as a driving force for cell migration, i.e., "flowtaxis", and investigation of molecular mechanosensors governing such behavior (e.g., ROCK as tested in this study) may provide new and improved insights into the fundamental understanding of cell migration-based homeostasis. The flow regimens could be controlled by the peristaltic pump and the Osci-Flow device, which were governed by StreamSoft v. 4.1 software provided by Flexcell® International Corp.”
At Flexcell® International Corporation, we understand that our commitment to the highest quality products and customer service depend on our ability to take part in research and development continuously. We invite you to read more about our ongoing research and development on cell stretching bioreactors in tissue engineering, cellular mechanics, gene and protein expression, cytomechanics, drug discovery, orthopedics, cardiovascular, and pulmonary research.